发明公开
- 专利标题: MICRONEEDLE DEVICE, AND METHOD FOR ENHANCING THE EFFICACY OF INFLUENZA VACCINE BY USING MICRONEEDLE DEVICE
- 专利标题(中): 微针装置和方法改进流感疫苗的效率利用微针装置
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申请号: EP09773249申请日: 2009-05-22
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公开(公告)号: EP2327419A4公开(公告)日: 2015-12-30
- 发明人: NOZAKI CHIKATERU , KAMINAKA KAZUYOSHI , MATSUDA JUNICHI , TERAHARA TAKAAKI , KUWAHARA TETSUJI , TOKUMOTO SEIJI
- 申请人: HISAMITSU PHARMACEUTICAL CO , CHEMO SERO THERAPEUT RES INST
- 专利权人: HISAMITSU PHARMACEUTICAL CO,CHEMO SERO THERAPEUT RES INST
- 当前专利权人: HISAMITSU PHARMACEUTICAL CO,CHEMO SERO THERAPEUT RES INST
- 优先权: JP2008170220 2008-06-30; JP2008267322 2008-10-16
- 主分类号: A61K39/145
- IPC分类号: A61K39/145 ; A61K9/00 ; A61K9/70 ; A61K39/00 ; A61K39/39 ; A61K47/10 ; A61K47/34 ; A61K47/36 ; A61L31/00 ; A61M37/00 ; A61P31/16
摘要:
The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
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