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1.发明公开MICRONEEDLE DEVICE, AND METHOD FOR ENHANCING THE EFFICACY OF INFLUENZA VACCINE BY USING MICRONEEDLE DEVICE 审中-公开微针装置和方法改进流感疫苗的效率利用微针装置
公开(公告)号：EP2327419A4
公开(公告)日：2015-12-30
申请号：EP09773249
申请日：2009-05-22
发明人： NOZAKI CHIKATERU , KAMINAKA KAZUYOSHI , MATSUDA JUNICHI , TERAHARA TAKAAKI , KUWAHARA TETSUJI , TOKUMOTO SEIJI
IPC分类号： A61K39/145 , A61K9/00 , A61K9/70 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/34 , A61K47/36 , A61L31/00 , A61M37/00 , A61P31/16
CPC分类号： A61K39/145 , A61B17/205 , A61K39/12 , A61K2039/5252 , A61K2039/541 , A61K2039/545 , A61K2039/55511 , A61K2039/70 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12N2760/16134 , C12N2760/16234
摘要： The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
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公开(公告)号：EP2392378A4
公开(公告)日：2014-03-26
申请号：EP10735768
申请日：2010-01-25
CPC分类号： A61L27/00 , A61K9/0021 , A61K38/1816 , A61K38/193 , A61K38/21 , A61K38/24 , A61K38/26 , A61K47/10 , A61K47/32 , A61M2037/0046
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公开(公告)号：EP2383013A4
公开(公告)日：2012-11-28
申请号：EP09835035
申请日：2009-12-25
CPC分类号： A61K38/29 , A61K9/0021 , A61K38/24 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053
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4.发明公开MICRONEEDLE DEVICE AND TRANSDERMAL ADMINISTRATION DEVICE PROVIDED WITH MICRONEEDLES 有权微针装置和透皮给药装置WITH MICRO NEEDLES
公开(公告)号：EP2005990A4
公开(公告)日：2011-04-27
申请号：EP07741173
申请日：2007-04-06
CPC分类号： A61M37/0015 , A61B17/205 , A61K9/0021 , A61M2037/0023
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5.发明公开ADJUVANT FOR TRANSDERMAL OR TRANSMUCOSAL ADMINISTRATION AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME 审中-公开经皮或经粘膜给药和药物制剂辅料材料，以便
公开(公告)号：EP2123296A4
公开(公告)日：2014-03-26
申请号：EP08710659
申请日：2008-01-31
IPC分类号： A61K39/39 , A61K9/00 , A61K9/70 , A61K31/075 , A61K31/08 , A61K31/095 , A61K31/12 , A61K31/121 , A61K31/125 , A61K31/13 , A61K31/325 , A61K31/327 , A61K47/10 , A61M37/00 , A61N1/04 , A61N1/30 , A61N1/32
CPC分类号： A61K47/10 , A61K9/0014 , A61K31/075 , A61K31/08 , A61K31/095 , A61K31/12 , A61K31/121 , A61K31/125 , A61K31/13 , A61K31/325 , A61K31/327 , A61K31/60 , A61K31/63 , A61K31/64 , A61K33/02 , A61K33/08 , A61K39/39 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61M2037/0061 , A61N1/0412 , A61N1/0428 , A61N1/30 , A61N1/325
摘要： It is intended to provide a low molecular weight adjuvant which can be administered safely without inducing skin irritation or the like by transdermal or transmucosal administration and is for enhancing immunogenicity of an antigen efficiently. It can be achieved by an immunostimulant adjuvant containing at least one substance selected from the group consisting of aliphatic alcohols, free fatty acids and fatty acid derivatives but does not contain a substance represented by the following formula. (In the formula, R 3 and R 4 may be combined to form a cyclic ring, and R 1 and R 2 independently represent an alkyl side chain having 1 to 16 carbon atoms.)
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公开(公告)号：EP1992386A4
公开(公告)日：2010-03-17
申请号：EP07713903
申请日：2007-02-07
CPC分类号： A61M37/0015 , A61M2037/0007 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61N1/306
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公开(公告)号：EP2119469A4
公开(公告)日：2011-06-22
申请号：EP08704452
申请日：2008-02-05
IPC分类号： A61M37/00
CPC分类号： A61B10/0035 , A61M37/0015 , A61M2037/0046
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公开(公告)号：EP2153863A4
公开(公告)日：2014-01-08
申请号：EP07830111
申请日：2007-10-18
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0053 , B81B2201/055 , B81B2203/0361 , B81C1/00206
摘要： The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device (22) with a plurality of microneedles (21) is mounted on a table (23), while a mask plate (25) with a plurality of apertures (24) is fixed to a frame member (26), and a coating solution (27) is drawn in the direction of arrow A on the mask plate (25) using a spatula (28) to fill the apertures (24) with the coating solution. The microneedles (21) are inserted in the apertures (24) before or after the filling of the apertures (24) with the coating solution (27) to coat the microneedles (21).
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9.发明公开TRANSDERMAL PREPARATION FOR EXTERNAL USE CONTAINING NONSTEROIDAL ANTIINFLAMMATORY/ANALGESIC AGENT 有权经皮给药制剂与非甾体消炎抑制剂/止痛外用使用
公开(公告)号：EP1872796A4
公开(公告)日：2009-08-26
申请号：EP06714545
申请日：2006-02-24
发明人： YOSHITAKE KAZUHISA , ATARASHI KENJI , KUWAHARA TETSUJI , IKESUE KOICHI , SAKAI MICHINORI , HASHIMOTO YOSHIAKI , TSURUDA KIYOMI
IPC分类号： A61K45/06 , A61K9/06 , A61K31/192 , A61K31/196 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/423 , A61K31/53 , A61K31/5415 , A61K47/08 , A61K47/10
CPC分类号： A61K9/0014 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/445 , A61K8/466 , A61K8/4946 , A61K9/7053 , A61K9/7061 , A61K31/192 , A61K31/196 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/423 , A61K31/53 , A61K31/5415 , A61K45/06 , A61Q17/04 , A61K2300/00
摘要： A transdermal preparation for external use which contains a photosensitive NSAID and a UV blocker having a high ability to migrate into the skin. Thus, it becomes possible to ensure, in a transdermal preparation for external use containing a NSAID, the inhibition of the onset of light-induced non-immunological or immunological skin symptoms by the above-described component.
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10.发明公开ADJUVANT OR PHARMACEUTICAL PREPARATION FOR TRANSDERMAL OR TRANSMUCOSAL ADMINISTRATION 有权ADJUVANS ODER PHARMAZEUTISCHE ZUBEREITUNG ZUR TRANSDERMALEN ODER TRANSMUKOSALEN VERABREICHUNG
公开(公告)号：EP1917976A4
公开(公告)日：2008-12-03
申请号：EP06781981
申请日：2006-07-31
CPC分类号： A61K39/39 , A61K9/0009 , A61K9/0014 , A61K9/0021 , A61K9/006 , A61K39/145 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61M37/0092 , A61N1/325 , A61N1/327 , C12N7/00 , C12N2760/16034
摘要： An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R 3 and R 4 may together form a cyclic ring, and R 1 and R 2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
摘要翻译： 1。一种透皮或经粘膜给药用佐剂，其含有选自脂肪族醇，游离脂肪酸和脂肪酸衍生物中的至少一种物质，但不含有下式表示的物质：其中R3和R4可以一起形成环 并且R 1和R 2独立地表示具有1至16个碳原子的烷基侧链。
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