发明公开
- 专利标题： METHOD FOR SYNTHESIZING PROTEIN CONTAINING HIGH CONTENT OF SPECIFIC AMINO ACID THROUGH SIMULTANEOUS EXPRESSION WITH TRNA OF THE SPECIFIC AMINO ACID
- 专利标题（中）： 合成与特定的氨基比例较高的蛋白质BY同时表达与特定的tRNA氨基方法
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申请号： EP09814823.2申请日： 2009-09-22
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公开(公告)号： EP2330186A2公开(公告)日： 2011-06-08
- 发明人: LEE, Sang Yup , XIA, Xiaoxia , QIAN, Zhi Gang , BAEK, Jong Hwan
- 申请人： Korea Advanced Institute of Science and Technology
- 申请人地址： 373-1, Guseong-dong Yuseong-gu Daejeon, 305-701 KR
- 专利权人： Korea Advanced Institute of Science and Technology
- 当前专利权人： Korea Advanced Institute of Science and Technology
- 当前专利权人地址： 373-1, Guseong-dong Yuseong-gu Daejeon, 305-701 KR
- 代理机构： Hiebl, Inge Elisabeth
- 优先权： KR20080092906 20080922
- 国际公布： WO2010033007 20100325
- 主分类号： C12N1/21
- IPC分类号： C12N1/21
摘要：
The present invention relates to a method of increasing the expression of a target protein by co-expression of a gene encoding a target protein having a high content of a specific amino acid with a nucleotide sequence encoding the tRNA of the specific amino acid. According to the present invention, the expression of a protein having a high content of a specific amino acid can be remarkably increased by co-expression with the tRNA of the specific amino acid. Thus, the present invention is useful for increasing the productivity of a protein having a high content of a specific amino acid, such as a repetitive protein.
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