发明公开
EP2331129A1 COMPOSITION COMPRISING A COMPLEXED (M)RNA AND A NAKED MRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF
有权
组合物，包含络合（M）RNA和mRNA的裸提供或改善哺乳动物中的和它们的应用的免疫应答
- 专利标题： COMPOSITION COMPRISING A COMPLEXED (M)RNA AND A NAKED MRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF
- 专利标题（中）： 组合物，包含络合（M）RNA和mRNA的裸提供或改善哺乳动物中的和它们的应用的免疫应答
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申请号： EP09736823.7申请日： 2009-09-30
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公开(公告)号： EP2331129A1公开(公告)日： 2011-06-15
- 发明人: FOTIN-MLECZEK, Mariola , VOSS, Söhnke
- 申请人： Curevac GmbH
- 申请人地址： Paul-Ehrlich-Str. 15 72076 Tübingen DE
- 专利权人： Curevac GmbH
- 当前专利权人： Curevac GmbH
- 当前专利权人地址： Paul-Ehrlich-Str. 15 72076 Tübingen DE
- 代理机构： Graf von Stosch, Andreas
- 优先权： PCT/EP2008/008304 20080930
- 国际公布： WO2010037539 20100408
- 主分类号： A61K39/39
- IPC分类号： A61K39/39 ; A61P35/00 ; A61K47/00
摘要：
The present invention relates to an immunostimulatory composition comprising a) an adjuvant component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound, and b) at least one free mRNA, encoding at least one therapeutically active protein, antigen, allergen and/or antibody, wherein the immunostimulatory composition is capable to elicit or enhance an innate and optionally an adaptive immune response in a mammal. The inventive immunostimulatory composition may be a pharmaceutical composition or a vaccine. The invention furthermore relates to a method of preparation of the inventive immunostimulatory composition. The invention also relates to the use of the inventive immunostimulatory composition or its components (for the preparation of a pharmaceutical composition or a vaccine) for the treatment of various diseases. Finally, the invention relates to kits containing the inventive immunostimulatory composition, its components and/or the pharmaceutical composition or vaccine.
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