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8 条记录 (耗时 0.027 秒)

    COMPLEXATION OF NUCLEIC ACIDS WITH DISULFIDE-CROSSLINKED CATIONIC COMPONENTS FOR TRANSFECTION AND IMMUNOSTIMULATION
    1.
    发明公开
    COMPLEXATION OF NUCLEIC ACIDS WITH DISULFIDE-CROSSLINKED CATIONIC COMPONENTS FOR TRANSFECTION AND IMMUNOSTIMULATION 有权
    与二硫键连接的阳离子成分用于转染和免疫刺激络合核酸

    公开(公告)号：EP2449113A1

    公开(公告)日：2012-05-09

    申请号：EP11738625.0

    申请日：2011-07-25

    申请人： Curevac GmbH

    发明人： BAUMHOF, Patrick ,  VOSS, Söhnke ,  KRAMPS, Thomas ,  KALLEN, Karl-Josef

    IPC分类号： C12N15/87 ,  A61K48/00 ,  A61K47/34 ,  A61K47/48

    CPC分类号： A61K48/0041 ,  A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  A61K47/645 ,  A61K2039/51 ,  A61K2039/55516 ,  A61K2039/55561 ,  C12N15/87 ,  Y02A50/412 ,  Y02A50/472

    摘要： The present invention is directed to a polymeric carrier cargo complex, comprising as a cargo at least one nucleic acid (molecule) and disulfide-crosslinked cationic components as a (preferably non-toxic and non-immunogenic) polymeric carrier. The inventive polymeric carrier cargo complex allows for both efficient transfection of nucleic acids into cells in vivo and in vitro and/or for induction of an (innate and/or adaptive) immune response, preferably dependent on the nucleic acid to be transported as a cargo. The present invention also provides, pharmaceutical compositions, particularly vaccines and adjuvants, comprising the inventive polymeric carrier cargo complex and optionally an antigen, as well as the use of such the inventive polymeric carrier cargo complex and optionally an antigen for transfecting a cell, a tissue or an organism, for (gene-)therapeutic purposes as disclosed herein, and/or as an immunostimulating agent or adjuvant, e.g. for eliciting an immune response for the treatment or prophylaxis of diseases as mentioned above. Finally, the invention relates to kits containing the inventive polymeric carrier cargo complex and/or the inventive pharmaceutical composition, adjuvant or vaccine in one or more parts of the kit.

    COMPOSITION COMPRISING A COMPLEXED (M)RNA AND A NAKED MRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF
    6.
    发明授权
    COMPOSITION COMPRISING A COMPLEXED (M)RNA AND A NAKED MRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF 有权
    组合物，包含络合（M）RNA和mRNA的裸提供或改善哺乳动物中的和它们的应用的免疫应答

    公开(公告)号：EP2331129B1

    公开(公告)日：2014-06-18

    申请号：EP09736823.7

    申请日：2009-09-30

    申请人： Curevac GmbH

    发明人： FOTIN-MLECZEK, Mariola ,  VOSS, Söhnke

    IPC分类号： A61K39/39 ,  A61P35/00 ,  A61K47/00

    CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/55511 ,  Y02A50/491

    摘要： The present invention relates to an immunostimulatory composition comprising a) an adjuvant component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound, and b) at least one free mRNA, encoding at least one therapeutically active protein, antigen, allergen and/or antibody, wherein the immunostimulatory composition is capable to elicit or enhance an innate and optionally an adaptive immune response in a mammal. The inventive immunostimulatory composition may be a pharmaceutical composition or a vaccine. The invention furthermore relates to a method of preparation of the inventive immunostimulatory composition. The invention also relates to the use of the inventive immunostimulatory composition or its components (for the preparation of a pharmaceutical composition or a vaccine) for the treatment of various diseases. Finally, the invention relates to kits containing the inventive immunostimulatory composition, its components and/or the pharmaceutical composition or vaccine.

    COMPOSITION COMPRISING A COMPLEXED (M)RNA AND A NAKED MRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF
    8.
    发明公开
    COMPOSITION COMPRISING A COMPLEXED (M)RNA AND A NAKED MRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF 有权
    组合物，包含络合（M）RNA和mRNA的裸提供或改善哺乳动物中的和它们的应用的免疫应答

    公开(公告)号：EP2331129A1

    公开(公告)日：2011-06-15

    申请号：EP09736823.7

    申请日：2009-09-30

    申请人： Curevac GmbH

    发明人： FOTIN-MLECZEK, Mariola ,  VOSS, Söhnke

    IPC分类号： A61K39/39 ,  A61P35/00 ,  A61K47/00

    CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/55511 ,  Y02A50/491

    摘要： The present invention relates to an immunostimulatory composition comprising a) an adjuvant component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound, and b) at least one free mRNA, encoding at least one therapeutically active protein, antigen, allergen and/or antibody, wherein the immunostimulatory composition is capable to elicit or enhance an innate and optionally an adaptive immune response in a mammal. The inventive immunostimulatory composition may be a pharmaceutical composition or a vaccine. The invention furthermore relates to a method of preparation of the inventive immunostimulatory composition. The invention also relates to the use of the inventive immunostimulatory composition or its components (for the preparation of a pharmaceutical composition or a vaccine) for the treatment of various diseases. Finally, the invention relates to kits containing the inventive immunostimulatory composition, its components and/or the pharmaceutical composition or vaccine.