发明公开
- 专利标题： PYRIMIDINYL PYRIDONE INHIBITORS OF JNK
- 专利标题（中）： 嘧啶的嘧啶基吡啶酮抑制剂
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申请号： EP09783971.6申请日： 2009-10-13
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公开(公告)号： EP2344502A2公开(公告)日： 2011-07-20
- 发明人: BOICE, Genevieve N. , GONG, Leyi , MCCALEB, Kristen Lynn , PALMER, Wylie Solang
- 申请人： F. Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F. Hoffmann-La Roche AG
- 当前专利权人： F. Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Salud, Carlos E.
- 优先权： US107532P 20081022
- 国际公布： WO2010046273 20100429
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; A61P29/00
摘要：
This application discloses novel pyrimidinyl pyridone derivatives according to Formulae I and II, wherein R
1 and R
2 are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of Formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of Formula I to a subject in need thereof.
1 and R
2 are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of Formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of Formula I to a subject in need thereof.
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