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12 条记录 (耗时 0.015 秒)

    NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
    2.
    发明公开
    NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 审中-公开
    非核苷反义转录酶抑制剂

    公开(公告)号：EP2134711A2

    公开(公告)日：2009-12-23

    申请号：EP08735604.4

    申请日：2008-03-31

    申请人： F. Hoffmann-La Roche AG

    发明人： BILLEDEAU, Roland J. ,  PALMER, Wylie Solang ,  SWEENEY, Zachary Kevin ,  WU, Jeffrey

    IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/4353 ,  A61K31/4162 ,  A61P31/18

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： Compounds of formula (I), wherein R1, R2, R3, R4, Ra, X, X1, and Y are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula (I) useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.

    摘要翻译： 其中R 1，R 2，R 3，R 4，R a，X，X 1和Y如本文所定义的式（I）化合物或其药学上可接受的盐抑制HIV-1逆转录酶并提供预防和治疗HIV的方法 -1感染和艾滋病和/或ARC的治疗。 本发明还涉及含有用于预防和治疗HIV-1感染和治疗AIDS和/或ARC的式（I）化合物的组合物。

    NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
    6.
    发明公开
    NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 有权
    非核苷反义转录酶抑制剂

    公开(公告)号：EP2057125A1

    公开(公告)日：2009-05-13

    申请号：EP07802503.8

    申请日：2007-08-06

    申请人： F. Hoffmann-La Roche AG

    发明人： KENNEDY-SMITH, Joshua ,  PALMER, Wylie Solang ,  SWEENEY, Zachary Kevin

    IPC分类号： C07D231/12 ,  C07D231/56 ,  C07D471/04 ,  C07D487/04 ,  A61K31/415 ,  A61K31/4162 ,  A61P31/18

    CPC分类号： C07D471/04 ,  C07D231/12 ,  C07D231/56 ,  C07D487/04

    摘要： The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A1, A2, A3 or A4 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X3, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.

    摘要翻译： 本发明提供可用于治疗HIV感染，或预防HIV感染，或治疗AIDS或ARC的化合物。 本发明的化合物是其中A是A1，A2，A3或A4并且R1，R2，R3，R4a，R4b，R5，R6，Ar，X1，X2，X3，X4和X5如本文所定义的式I的化合物。 本发明还公开了用本文定义的化合物治疗HIV感染的方法和含有所述化合物的药物组合物。

    PYRIMIDINYL PYRIDONE INHIBITORS OF JNK
    8.
    发明公开
    PYRIMIDINYL PYRIDONE INHIBITORS OF JNK 审中-公开
    嘧啶的嘧啶基吡啶酮抑制剂

    公开(公告)号：EP2344502A2

    公开(公告)日：2011-07-20

    申请号：EP09783971.6

    申请日：2009-10-13

    申请人： F. Hoffmann-La Roche AG

    发明人： BOICE, Genevieve N. ,  GONG, Leyi ,  MCCALEB, Kristen Lynn ,  PALMER, Wylie Solang

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P29/00

    CPC分类号： C07D471/04

    摘要： This application discloses novel pyrimidinyl pyridone derivatives according to Formulae I and II, wherein R
    1 and R
    2 are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of Formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of Formula I to a subject in need thereof.

    摘要翻译： 该申请公开了根据式I和II的新型嘧啶基吡啶酮衍生物，其中R 1和R 2如本文所述定义，其抑制JNK。 本文公开的化合物可用于调节JNK的活性并治疗与过量的JNK活性相关的疾病。 该化合物可用于治疗自身免疫疾病，炎症，代谢疾病和神经疾病以及癌症。 还公开了包含式I化合物的组合物和治疗方法，其包括将治疗有效量的式I化合物给予有需要的受试者。