发明公开
EP2344660A4 METHODS AND COMPOSITIONS FOR INACTIVATING GLUTAMINE SYNTHETASE GENE EXPRESSION
有权
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR INAKTIVIERUNG EINER GLUTAMINSYNTHETASE-GENEXPRESSION
- 专利标题： METHODS AND COMPOSITIONS FOR INACTIVATING GLUTAMINE SYNTHETASE GENE EXPRESSION
- 专利标题（中）： VERFAHREN UND ZUSAMMENSETZUNGEN ZUR INAKTIVIERUNG EINER GLUTAMINSYNTHETASE-GENEXPRESSION
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申请号： EP09825094申请日： 2009-10-29
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公开(公告)号： EP2344660A4公开(公告)日： 2013-05-29
- 发明人: LIU PEI-QI , MILLER JEFFREY C
- 申请人： SANGAMO BIOSCIENCES INC
- 专利权人： SANGAMO BIOSCIENCES INC
- 当前专利权人： SANGAMO BIOSCIENCES INC
- 优先权： US19760008 2008-10-29
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00 ; C12N15/11 ; C12N15/62 ; C12Q1/16
摘要：
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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