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1.发明公开METHODS AND COMPOSITIONS FOR GENOME ENGINEERING 审中-公开VERFAHREN UND ZUSAMMENSETZUNGENFÜRGENOM-ENGINEERING
公开(公告)号：EP3080274A4
公开(公告)日：2017-06-21
申请号：EP14869719
申请日：2014-12-09
发明人： MILLER JEFFREY C , PASCHON DAVID , REBAR EDWARD J , WECHSLER THOMAS , ZHANG LEI
CPC分类号： C07K14/47 , A61K48/00 , C07K14/4702 , C07K2319/81 , C12N9/22 , C12N9/644 , C12N15/86 , C12N2750/14133 , C12N2750/14142 , C12N2750/14143
摘要： Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins involved in clotting into the genome of a cell for treating conditions including hemophilias.
摘要翻译： 本文公开了用于插入转基因序列的方法和组合物，所述转基因序列编码涉及凝结成细胞基因组的蛋白质以治疗包括血友病的病症。
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2.发明公开METHODS AND COMPOSITIONS FOR TARGETED CLEAVAGE AND RECOMBINATION 有权VERFAHREN UND ZUSAMMENSETZUNGEN ZUR GEZIELTEN SPALTUNG UND REKOMBINATION
公开(公告)号：EP1651660A4
公开(公告)日：2012-05-23
申请号：EP04780272
申请日：2004-08-06
CPC分类号： C12N15/10 , C07K14/4702 , C07K2319/00 , C07K2319/81 , C12N9/22 , C12N15/902
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to M the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.
摘要翻译： 本文公开了用于基因组序列的靶向切割，基因组序列的靶向改变以及基因组区域和与该基因组区域同源的外源多核苷酸之间的靶向重组的方法和组合物。 组合物包括包含切割结构域（或切割半结构域）和工程化锌指结构域的融合蛋白和编码它们的多核苷酸。 用于靶向切割的方法包括将这种融合蛋白或编码其的多核苷酸引入细胞。 靶向重组的方法还包括将与基因组区域同源的外源多核苷酸引入包含所公开的融合蛋白的细胞中。
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3.发明公开METHODS AND COMPOSITIONS FOR TREATING HEMOPHILIA 审中-公开VERFAHREN UND ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VONHÄMOPHILIE
公开(公告)号：EP3080143A4
公开(公告)日：2017-06-14
申请号：EP14869305
申请日：2014-12-09
发明人： MILLER JEFFREY C , PASCHON DAVID , REBAR EDWARD J
CPC分类号： C07K14/47 , A61K48/00 , C07K14/4702 , C07K2319/81 , C12N9/22 , C12N9/644 , C12N15/86 , C12N2750/14133 , C12N2750/14142 , C12N2750/14143
摘要： Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins involved in clotting into the genome of a cell for treating conditions including hemophilias.
摘要翻译： 本文公开了用于插入转基因序列的方法和组合物，所述转基因序列编码涉及凝结成细胞基因组的蛋白质以治疗包括血友病的病症。
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4.发明公开METHODS AND COMPOSITIONS FOR INTEGRATION OF AN EXOGENOUS SEQUENCE WITHIN THE GENOME OF PLANTS 审中-公开方法和组合物外源序列在植物的基因组整合
公开(公告)号：EP2981166A4
公开(公告)日：2017-03-01
申请号：EP14778180
申请日：2014-04-02
发明人： AINLEY W MICHAEL , GUSCHIN DMITRY Y , HAYDEN MATTHEW , ISENEGGER DANIEL , MASON JOHN , MILLER JEFFREY C , PETOLINO JOSEPH F , RAN YIDONG , SAWBRIDGE TIM , SPANGENBERG GERMAN , WEBB STEVEN R
IPC分类号： A01H1/00
CPC分类号： C12N15/8213 , C12N15/8274 , C12N15/8278 , C12N15/90 , C12N2800/80
摘要： Disclosed herein are methods and compositions for parallel or sequential transgene stacking in plants to produce plants with selected phenotypes.
摘要翻译： 公开在用于并行或顺序堆叠的转基因植物，以产生与选定的表型的植物的方法和组合物。
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5.发明公开FAD2 PERFORMANCE LOCI AND CORRESPONDING TARGET SITE SPECIFIC BINDING PROTEINS CAPABLE OF INDUCING TARGETED BREAKS 审中-公开FAD2演出场所和相关的目标定特异性结合蛋白，以确保靶向BREAKS
公开(公告)号：EP2892321A4
公开(公告)日：2016-03-02
申请号：EP13834776
申请日：2013-09-05
发明人： AINLEY WILLIAM MICHAEL , WEBB STEVEN R , SAMUEL PON , GUSCHIN DMITRY Y , MILLER JEFFREY C , ZHANG LEI
CPC分类号： C12N15/8216 , C07K14/4702 , C07K2319/81 , C12N9/22 , C12N15/102 , C12N15/66 , C12N15/822 , C12N15/8247 , C12N15/902 , C12Y301/00
摘要： Methods and compositions for gene disruption, gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a soybean cell, to generate a break in the FAD2 gene and then optionally integrating into the break a nucleic acid molecule of interest is disclosed.
摘要翻译： 方法和组合物基因破坏，基因编辑或基因通过切割，在一个定点方式一个FAD2基因座内堆叠，在大豆细胞中的FAD2基因的位置，以产生在所述FAD2基因中断，然后任选INTEGRA廷入 打破感兴趣的核酸分子游离缺失盘。
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6.发明公开METHODS AND COMPOSITIONS FOR MODIFICATION OF A HLA LOCUS 审中-公开VERFAHREN UND ZUSAMMENSETZUNGEN ZUR VERNDNDUNG EINES HLA-LOCUS
公开(公告)号：EP2596011A4
公开(公告)日：2014-03-19
申请号：EP11810427
申请日：2011-07-21
发明人： COLLINGWOOD TREVOR , COOPER LAURENCE J N , GREGORY PHILIP D , HOLMES MICHAEL C , MILLER JEFFREY C , REBAR EDWARD J , REIK ANDREAS , URNOV FYODOR
IPC分类号： C07K14/00
CPC分类号： C07K14/70539 , A61K35/17 , C07K2319/81 , C12N15/907 , C12N2800/80
摘要： Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
摘要翻译： 本文公开了用于调节HLA基因座表达或选择性删除或操纵HLA基因座或HLA调节剂的方法和组合物。
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公开(公告)号：EP2534173A4
公开(公告)日：2013-07-17
申请号：EP11740153
申请日：2011-02-07
发明人： DOYON YANNICK , MILLER JEFFREY C
IPC分类号： C07K14/195 , C12N9/22
CPC分类号： C12N15/907 , C07K7/06 , C07K14/47 , C07K2319/50 , C07K2319/80 , C07K2319/81 , C12N9/22 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.
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8.发明公开METHODS AND COMPOSITIONS FOR INACTIVATING GLUTAMINE SYNTHETASE GENE EXPRESSION 有权VERFAHREN UND ZUSAMMENSETZUNGEN ZUR INAKTIVIERUNG EINER GLUTAMINSYNTHETASE-GENEXPRESSION
公开(公告)号：EP2344660A4
公开(公告)日：2013-05-29
申请号：EP09825094
申请日：2009-10-29
发明人： LIU PEI-QI , MILLER JEFFREY C
CPC分类号： C12N15/85 , C07K14/00 , C12N9/22 , C12N9/93 , C12N2510/00 , C12P21/02 , C12Y603/01002 , Y02P20/52
摘要： Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
摘要翻译： 本文公开了使用包含锌指蛋白和切割结构域或裂解半结构域的融合蛋白来灭活谷氨酰胺合成酶（GS）基因的方法和组合物。 还提供编码所述融合蛋白的多核苷酸，以及包含所述多核苷酸和融合蛋白的细胞。
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公开(公告)号：EP3152319A4
公开(公告)日：2017-12-27
申请号：EP15803156
申请日：2015-06-05
发明人： DOYON YANNICK , MILLER JEFFREY C
CPC分类号： C12N15/01 , C07K2319/00 , C07K2319/80 , C12N9/22 , C12N15/102 , C12N15/63 , C12Y301/00
摘要： Methods and compositions for genetic alteration of cells are provided.
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公开(公告)号：EP3151846A4
公开(公告)日：2017-12-27
申请号：EP15803590
申请日：2015-06-05
发明人： MILLER JEFFREY C
CPC分类号： C12N15/01 , C07K2319/00 , C07K2319/80 , C12N9/22 , C12N15/102 , C12N15/63 , C12Y301/00
摘要： Methods and compositions for genetic alteration of cells are provided.
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