发明公开
EP2348857A1 NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS
有权
新的循环的苯并咪唑衍生物作为抗糖尿病患者
- 专利标题： NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS
- 专利标题（中）： 新的循环的苯并咪唑衍生物作为抗糖尿病患者
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申请号： EP09822430.6申请日： 2009-10-12
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公开(公告)号： EP2348857A1公开(公告)日： 2011-08-03
- 发明人: BOOKSER, Brett, C. , DANG, Qun , GIBSON, Tony, S. , JIANG, Hongjian , CHUNG, De Michael , BAO, Jianming , JIANG, Jinlong , KASSICK, Andy , KEKEC, Ahmet , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F., Anthony , SEBHAT, Iyassu , WILSON, David , WODKA, Dariusz
- 申请人： Merck Sharp & Dohme Corp. , Metabasis Therapeutics, Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.,Metabasis Therapeutics, Inc.
- 当前专利权人： Merck Sharp & Dohme Corp.,Metabasis Therapeutics, Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Jaap, David Robert
- 优先权： US196949P 20081022
- 国际公布： WO2010047982 20100429
- 主分类号： A01N43/50
- IPC分类号： A01N43/50 ; A61K31/415 ; C07D243/08
摘要：
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
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