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公开(公告)号：EP2348857B1
公开(公告)日：2016-02-24
申请号：EP09822430.6
申请日：2009-10-12
发明人： BOOKSER, Brett, C. , DANG, Qun , GIBSON, Tony, S. , JIANG, Hongjian , CHUNG, De Michael , BAO, Jianming , JIANG, Jinlong , KASSICK, Andy , KEKEC, Ahmet , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F., Anthony , SEBHAT, Iyassu , WILSON, David , WODKA, Dariusz
IPC分类号： C07F9/6506 , C07F9/6558 , C07F9/6571 , A61K31/415
CPC分类号： C07F9/65068 , C07F9/65583 , C07F9/657181
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公开(公告)号：EP2352374B1
公开(公告)日：2014-09-24
申请号：EP09824011.2
申请日：2009-10-19
发明人： DANG, Qun , CHUNG, De Michael , GIBSON, Tony, S. , JIANG, Hongjian , CASHION, Daniel, K. , BAO, Jianming , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F., Anthony , SEBHAT, Iyassu , WODKA, Dariusz
IPC分类号： C07D235/26 , C07D235/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04 , A61K31/4184
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
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公开(公告)号：EP2352374A1
公开(公告)日：2011-08-10
申请号：EP09824011.2
申请日：2009-10-19
发明人： DANG, Qun , CHUNG, De Michael , GIBSON, Tony, S. , JIANG, Hongjian , CASHION, Daniel, K. , BAO, Jianming , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F., Anthony , SEBHAT, Iyassu , WODKA, Dariusz
IPC分类号： A01N43/52
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的激活剂并且可用于治疗，预防和抑制由AMPK-活化的蛋白激酶介导的疾病。 本发明化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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公开(公告)号：EP2348857A1
公开(公告)日：2011-08-03
申请号：EP09822430.6
申请日：2009-10-12
发明人： BOOKSER, Brett, C. , DANG, Qun , GIBSON, Tony, S. , JIANG, Hongjian , CHUNG, De Michael , BAO, Jianming , JIANG, Jinlong , KASSICK, Andy , KEKEC, Ahmet , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F., Anthony , SEBHAT, Iyassu , WILSON, David , WODKA, Dariusz
IPC分类号： A01N43/50 , A61K31/415 , C07D243/08
CPC分类号： C07F9/65068 , C07F9/65583 , C07F9/657181
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
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公开(公告)号：EP3924343A1
公开(公告)日：2021-12-22
申请号：EP09792782.6
申请日：2009-09-21
发明人： BOOKSER, Brett, C. , DANG, Qun , GIBSON, Tony, S. , JIANG, Hongjian , CHUNG, De Michael , BAO, Jianming , JIANG, Jinlong , KASSICK, Andy , KEKEC, Ahmet , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F. Anthony , SEBHAT, Iyassu , WILSON, David , WODKA, Dariusz
IPC分类号： C07D235/26 , C07D235/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K31/4184 , A61K31/4439 , A61P3/10
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6.发明授权
公开(公告)号：EP2362731B1
公开(公告)日：2016-04-06
申请号：EP09824027.8
申请日：2009-10-22
发明人： DANG, Qun , CHUNG, De Michael , GIBSON, Tony, S. , JIANG, Hongjian , CASHION, Daniel, K. , BAO, Jianming , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F. Anthony , SEBHAT, Iyassu , WODKA, Dariusz
IPC分类号： A61K31/366 , C07F9/6506 , C07F9/6574 , A61K31/415 , A61K31/397 , A61K31/4184 , A01N43/50 , A61K31/4412 , A61K45/06 , C07F9/6558
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
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7.发明公开
公开(公告)号：EP2362731A1
公开(公告)日：2011-09-07
申请号：EP09824027.8
申请日：2009-10-22
发明人： DANG, Qun , CHUNG, De Michael , GIBSON, Tony, S. , JIANG, Hongjian , CASHION, Daniel, K. , BAO, Jianming , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F. Anthony , SEBHAT, Iyassu , WODKA, Dariusz
IPC分类号： A01N43/50 , A61K31/415 , C07D243/08
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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公开(公告)号：EP2888007A1
公开(公告)日：2015-07-01
申请号：EP13830944.8
申请日：2013-08-15
发明人： APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , FENG, Danqing , HICKS, Jacqueline, D. , KEKEC, Ahmet , LEAVITT, Kenneth, J. , LI, Bing , SEBHAT, Iyassu , QIAN, Xiaoxia , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
IPC分类号： A61P3/10 , A61K31/4184 , A61K31/415 , A61K31/454
CPC分类号： C07D417/14 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/427 , A61K31/4985 , A61K31/506 , A61K31/5377 , C07D405/12 , C07D405/14 , C07D413/14
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的激活剂，并且可用于治疗，预防和抑制由AMPK-活化的蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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公开(公告)号：EP2888008B1
公开(公告)日：2018-12-26
申请号：EP13831336.6
申请日：2013-08-19
发明人： APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , FENG, Danqing , HICKS, Jacqueline, D. , KEKEC, Ahmet , LEAVITT, Kenneth, J. , LI, Bing , SEBHAT, Iyassu , QIAN, Xiaoxia , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai , ARASAPPAN, Ashok
IPC分类号： C07D471/04 , C07D519/00 , A61P3/10 , A61K31/4184 , A61K31/415 , A61K31/454
CPC分类号： C07D471/04 , A61K31/19 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/5377 , C07C53/18 , C07D519/00 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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10.发明授权
公开(公告)号：EP2677869B1
公开(公告)日：2017-11-08
申请号：EP12749051.4
申请日：2012-02-23
发明人： ANAND, Rajan , APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , CHU, Lin , COLANDREA, Vincent, J. , DONG, Guizhen , DROPINSKI, James, F. , FENG, Danqing , HICKS, Jacqueline, D. , JIANG, Jinlong , KIM, Alexander, J. , LEAVITT, Kenneth, J. , LI, Bing , QIAN, Xiaoxia , SEBHAT, Iyassu , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
IPC分类号： A01N43/58
CPC分类号： A61K31/5377 , A61K31/351 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/4412 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K45/06 , C07D471/04 , C07D519/00 , A61K2300/00
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