发明公开
- 专利标题： ATROPISOMERS OF (HYDROXYALKYL) PYRROLE DERIVATIVES
- 专利标题（中）： 作者（羟烷基）吡咯阻转异构体
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申请号： EP09737501.8申请日： 2009-10-07
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公开(公告)号： EP2349997A1公开(公告)日： 2011-08-03
- 发明人: NUSS, John , WILLIAMS, Matthew , MOHAN, Raju , MARTIN, Richard , WANG, Tie-Lin , AOKI, Kazumasa , TSURUOKA, Hiroyuki , HAYASHI, Noriyuki , HOMMA, Tsuyoshi
- 申请人： Exelixis, Inc. , Daiichi Sankyo Company, Limited
- 申请人地址： 210 East Grand Avenue P.O. Box 511 South San Francisco, CA 94083-0511 US
- 专利权人： Exelixis, Inc.,Daiichi Sankyo Company, Limited
- 当前专利权人： Exelixis, Inc.,Daiichi Sankyo Company, Limited
- 当前专利权人地址： 210 East Grand Avenue P.O. Box 511 South San Francisco, CA 94083-0511 US
- 代理机构： Main, Malcolm Charles
- 优先权： US103715P 20081008
- 国际公布： WO2010042622 20100415
- 主分类号： C07D207/34
- IPC分类号： C07D207/34 ; A61K31/40 ; A61P9/00
摘要：
The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases. The compound is an atropisomer of a compound represented by the following general formula (I ) : wherein R
1 represents a C1-C3 alkyl group; R
2 represents a 2-hydroxy- C4-C6 alkyl group; R
3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R
4 represents a hydrogen atom, a halogeno group and the like; R
5 represents a C1-C3 alkyl group; and R
6 represents a hydrogen atom, a halogeno group and the like] or atropisomers thereof.
1 represents a C1-C3 alkyl group; R
2 represents a 2-hydroxy- C4-C6 alkyl group; R
3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R
4 represents a hydrogen atom, a halogeno group and the like; R
5 represents a C1-C3 alkyl group; and R
6 represents a hydrogen atom, a halogeno group and the like] or atropisomers thereof.
公开/授权文献
- EP2349997B1 ATROPISOMERS OF (HYDROXYALKYL) PYRROLE DERIVATIVES 公开/授权日：2015-08-12
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