发明公开
EP2350023A1 6-PHENYL-PYRIMIDIN-4-YL-(PHENYLAMINE OR PHENOXY) DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
审中-公开
6-苯基 - 嘧啶-4-基（PHENYLAMIN-或苯氧基）衍生物作为烟碱乙酰胆碱受体的调节剂
- 专利标题： 6-PHENYL-PYRIMIDIN-4-YL-(PHENYLAMINE OR PHENOXY) DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
- 专利标题（中）： 6-苯基 - 嘧啶-4-基（PHENYLAMIN-或苯氧基）衍生物作为烟碱乙酰胆碱受体的调节剂
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申请号： EP09783889.0申请日： 2009-10-09
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公开(公告)号： EP2350023A1公开(公告)日： 2011-08-03
- 发明人: NARDI, Antonio , CHRISTENSEN, Jeppe, Kejser , PETERS, Dan
- 申请人： NeuroSearch A/S
- 申请人地址： Pederstrupvej 93 2750 Ballerup DK
- 专利权人： NeuroSearch A/S
- 当前专利权人： NeuroSearch A/S
- 当前专利权人地址： Pederstrupvej 93 2750 Ballerup DK
- 代理机构： Abildgren, Michael Padkjaer
- 优先权： DK200801421 20081009; US104356P 20081010; DK200900604 20090512
- 国际公布： WO2010040826 20100415
- 主分类号： C07D239/34
- IPC分类号： C07D239/34 ; C07D239/42 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; A61K31/505 ; A61K31/506 ; A61P25/00
摘要：
This invention relates to novel 6-phenyl-pyhmidin-4-yl-(phenylannine or phenoxy) derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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