公开(公告)号：EP2430020A1

公开(公告)日：2012-03-21

申请号：EP10716360.2

申请日：2010-05-06

申请人： NeuroSearch A/S

发明人： PETERS, Dan ,  NIELSEN, Elsebet, Østergaard ,  NIELSEN, Karin, Sandager ,  MUNRO, Gordon

IPC分类号： C07D451/06 ,  A61K31/46

CPC分类号： C07D451/06 ,  A61K31/46

摘要： The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)- chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors. In other aspects the applications discloses the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

公开(公告)号：EP2414364A1

公开(公告)日：2012-02-08

申请号：EP10711887.9

申请日：2010-03-30

申请人： NeuroSearch A/S

发明人： SØRENSEN, Ulrik, Svane ,  ERIKSEN, Birgitte, L. ,  STRØBÆK, Dorte ,  CHRISTOPHERSEN, Palle

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28

CPC分类号： C07D487/04

摘要： This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines useful as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention. Formula (I).

公开(公告)号：EP2387562A1

公开(公告)日：2011-11-23

申请号：EP10700997.9

申请日：2010-01-18

申请人： NeuroSearch A/S

发明人： NARDI, Antonio ,  ERICHSEN, Helle Kirstein ,  TROELSEN, Karin de Linde

IPC分类号： C07D215/22 ,  C07D401/06 ,  A61K31/4704 ,  A61K31/4709 ,  A61P25/00

CPC分类号： C07D215/22 ,  C07D401/06

摘要： The present invention relates to novel quinolinone derivatives (I), efficacious in animal models of CNS disorders and, as such, valuable candidates for the prevention or treatment of CNS (Central Nervous System) diseases or disorders. In other aspects the invention relates to pharmaceutical compositions comprising the quinolinone derivatives of the invention and to the use of these compounds for therapeutic applications.

公开(公告)号：EP2194056B1

公开(公告)日：2011-08-03

申请号：EP10154049.0

申请日：2007-05-29

申请人： NeuroSearch A/S

发明人： Peters, Dan ,  Olsen, Gunnar, M. ,  Nielsen, Elsebet, Østergaard ,  Timmermann, Daniel, B. ,  Loechel, Steven, Charles ,  Mikkelsen, Jens, Damsgaard ,  Hansen, Henrik, Björk ,  Redrobe, John, Paul ,  Christensen, Jeppe, Kejser ,  Dyhring, Tino

IPC分类号： C07D471/08 ,  A61K31/551 ,  A61P25/00

CPC分类号： C07D471/08

公开(公告)号：EP2344501A1

公开(公告)日：2011-07-20

申请号：EP09783277.8

申请日：2009-09-22

申请人： NeuroSearch A/S

发明人： ERIKSEN, Birgitte, L. ,  HOUGAARD, Charlotte ,  PETERS, Dan ,  CHRISTOPHERSEN, Palle

IPC分类号： C07D473/16 ,  A61K31/52 ,  A61P3/10 ,  A61P9/00 ,  A61P11/00 ,  A61P13/00 ,  A61P25/00

CPC分类号： C07D473/16

摘要： This invention relates to novel substituted purinyl-pyrazol derivatives (I) and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

公开(公告)号：EP1797088B1

公开(公告)日：2011-01-05

申请号：EP05792113.2

申请日：2005-09-28

申请人： NeuroSearch A/S

发明人： PETERS, Dan c/o NeuroSearch A/S ,  OLSEN, Gunnar, M. c/o NeuroSearch A/S ,  SCHEEL-KRÜGER, Jørgen c/o NeuroSearch A/S ,  NIELSEN, Elsebet, Østergaard c/o NeuroSearch A/S

IPC分类号： C07D451/06 ,  A61K31/137 ,  A61K31/428 ,  A61K31/46 ,  A61P25/16 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30

CPC分类号： C07D405/12 ,  C07D451/06 ,  C07D451/12

摘要： This invention relates to novel chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

公开(公告)号：EP1917264B1

公开(公告)日：2010-11-17

申请号：EP06763927.8

申请日：2006-06-28

申请人： NeuroSearch A/S

发明人： ERIKSEN, Birgitte L. c/o NeuroSearch A/S ,  PETERS, Dan c/o NeuroSearch A/S ,  NIELSEN, Elsebet, Østergaard c/o NeuroSearch A/S ,  REDROBE, John Paul c/o NeuroSearch A/S

IPC分类号： C07D471/10 ,  A61K31/438 ,  A61P25/00

CPC分类号： C07D471/10

摘要： This invention relates to novel 3,9-diaza-spiro[5.5]undecane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

公开(公告)号：EP2121677B1

公开(公告)日：2010-11-03

申请号：EP07857757.4

申请日：2007-12-18

申请人： NeuroSearch A/S

发明人： PETERS, Dan ,  REDROBE, John, Paul ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet Østergaard

IPC分类号： C07D451/06 ,  A61K31/46 ,  A61P25/00

CPC分类号： C07D451/06

摘要： This invention relates to novel chromen-2-one derivatives of Formula (I) useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

公开(公告)号：EP2235006A1

公开(公告)日：2010-10-06

申请号：EP08861973.9

申请日：2008-12-18

申请人： NeuroSearch A/S

发明人： PETERS, Dan ,  MUNRO, Gordon ,  NIELSEN, Elsebet, Østergaard

IPC分类号： C07D405/06 ,  A61K31/4468 ,  A61P25/00

CPC分类号： C07D405/06

摘要： This invention relates to novel /\/-aryl-/\/-piperidin-4-yl-propionamide derivatives useful as opioid receptor ligands. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of pain, and to pharmaceutical compositions comprising the compounds of the invention.

摘要翻译： 本发明涉及用作阿片受体配体的新的N-芳基-N-哌啶-4-基丙酰胺衍生物。 在其它方面，本发明涉及这些化合物在用于治疗的方法例如用于治疗疼痛的用途中的用途，以及涉及包含本发明化合物的药物组合物。

公开(公告)号：EP2231610A1

公开(公告)日：2010-09-29

申请号：EP08859320.7

申请日：2008-12-10

申请人： NeuroSearch A/S

发明人： BROWN, William, Dalby ,  JESSEN, Carsten ,  STRØBÆK, Dorte

IPC分类号： C07D213/75 ,  A61K31/44 ,  A61P29/00

CPC分类号： C07D213/75

摘要： This invention relates to novel 2-dimethylamino-3-amido-6-amino-pyhdine derivatives having medical utility, to use of the 2-dimethylamino-3-amido-6-amino- pyridine derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2-dimethylamino-3-amido-6-amino- pyridine derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of Kv7 channels.