发明公开
EP2352828A1 METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR INCREASING THE FUNCTIONAL ACTIVITY AND CELL SURFACE EXPRESSION OF CF-ASSOCIATED MUTANT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
有权
方法化合物用于增加CF ASSOZIERTEM突变囊性纤维化跨膜传导调节剂的活性鉴定（CFTR）
- 专利标题： METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR INCREASING THE FUNCTIONAL ACTIVITY AND CELL SURFACE EXPRESSION OF CF-ASSOCIATED MUTANT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
- 专利标题（中）： 方法化合物用于增加CF ASSOZIERTEM突变囊性纤维化跨膜传导调节剂的活性鉴定（CFTR）
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申请号： EP09782853.7申请日： 2009-09-10
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公开(公告)号： EP2352828A1公开(公告)日： 2011-08-10
- 发明人: FISCHER, David Frederik , JANSSEN, Richard Antonius Jozef , ROSEBOOM, Marjet , SCAFFIDI, Amelia Katie , TESSARI, Michela
- 申请人： Galapagos N.V.
- 申请人地址： Generaal de Wittelaan L11 A3 2800 Mechelen BE
- 专利权人： Galapagos N.V.
- 当前专利权人： Galapagos N.V.
- 当前专利权人地址： Generaal de Wittelaan L11 A3 2800 Mechelen BE
- 代理机构： Nichol, Maria Zenarosa
- 优先权： US191809P 20080911
- 国际公布： WO2010029118 20100318
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; G01N33/50 ; G01N33/68
摘要：
The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF- associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
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