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1.发明公开METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR INCREASING THE FUNCTIONAL ACTIVITY AND CELL SURFACE EXPRESSION OF CF-ASSOCIATED MUTANT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 有权方法化合物用于增加CF ASSOZIERTEM突变囊性纤维化跨膜传导调节剂的活性鉴定（CFTR）
公开(公告)号：EP2352828A1
公开(公告)日：2011-08-10
申请号：EP09782853.7
申请日：2009-09-10
申请人： Galapagos N.V.
发明人： FISCHER, David Frederik , JANSSEN, Richard Antonius Jozef , ROSEBOOM, Marjet , SCAFFIDI, Amelia Katie , TESSARI, Michela
CPC分类号： G01N33/5041 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2320/12 , C12N2330/31 , C12N2330/51 , C12Q1/6883 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/382
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF- associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
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2.发明授权METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR INCREASING THE FUNCTIONAL ACTIVITY AND CELL SURFACE EXPRESSION OF CF-ASSOCIATED MUTANT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 有权方法化合物用于增加CF ASSOZIERTEM突变囊性纤维化跨膜传导调节剂的活性鉴定（CFTR）
公开(公告)号：EP2352828B1
公开(公告)日：2015-02-25
申请号：EP09782853.7
申请日：2009-09-10
申请人： Galapagos N.V.
发明人： FISCHER, David Frederik , JANSSEN, Richard Antonius Jozef , ROSEBOOM, Marjet , SCAFFIDI, Amelia Katie , TESSARI, Michela
CPC分类号： G01N33/5041 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2320/12 , C12N2330/31 , C12N2330/51 , C12Q1/6883 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/382
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