发明公开
EP2356133A2 RECOMBINANT PROTEIN BODIES AS IMMUNOGEN-SPECIFIC ADJUVANTS 审中-公开
重组蛋白体AS IMMUNOGENSPEZIFISCHE佐剂

RECOMBINANT PROTEIN BODIES AS IMMUNOGEN-SPECIFIC ADJUVANTS
摘要:
An immunogen-specific is adjuvant for a vaccine or inoculum is disclosed. The adjuvant is comprised of particulate recombinant protein body-like assemblies (RPBLAs) that contain a recombinant fusion protein that contains two portions peptide-linked together. A first portion is a protein body-inducing sequence (PBIS) and a second portion is a T-cell stimulating immunogenic polypeptide whose sequence is that of a pathogenic polypeptide sequence present in or induced by a vaccine or inoculum. The adjuvant, when used as an inoculum in a host animal without a prior priming vaccination or inoculation, does not induce production of antibodies or T cell activation to the pathogenic sequence.
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