发明公开
EP2361918A1 NOVEL PROSTAGLANDIN E1 DERIVATIVE, AND NANOPARTICLE HAVING SAME ENCAPSULATED THEREIN
审中-公开
消除了PROSTAGLANDIN-E1-DERIVAT UND NANOPARTIKEL，DEM DIESES VERKAPSELT IST
- 专利标题： NOVEL PROSTAGLANDIN E1 DERIVATIVE, AND NANOPARTICLE HAVING SAME ENCAPSULATED THEREIN
- 专利标题（中）： 消除了PROSTAGLANDIN-E1-DERIVAT UND NANOPARTIKEL，DEM DIESES VERKAPSELT IST
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申请号： EP09827450.9申请日： 2009-10-16
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公开(公告)号： EP2361918A1公开(公告)日： 2011-08-31
- 发明人: MIZUSHIMA, Toru , OHTSUKA, Masami , OKAMOTO, Yoshinari
- 申请人： LTT Bio-Pharma Co., Ltd.
- 申请人地址： 2-20, Kaigan 1-chome Minato-ku Tokyo 105-0022 JP
- 专利权人： LTT Bio-Pharma Co., Ltd.
- 当前专利权人： LTT Bio-Pharma Co., Ltd.
- 当前专利权人地址： 2-20, Kaigan 1-chome Minato-ku Tokyo 105-0022 JP
- 代理机构： Albrecht, Thomas
- 优先权： JP2008294167 20081118
- 国际公布： WO2010058669 20100527
- 主分类号： C07F9/09
- IPC分类号： C07F9/09 ; A61K9/16 ; A61K31/661 ; A61K47/18 ; A61K47/22 ; A61K47/24 ; A61K47/34 ; A61P7/02 ; A61P43/00
摘要：
A PGE1 derivative is provided which has an excellent sustained, slow-release PGE1 action. In addition, a PGE1-derivative-containing nanoparticle produced using this PGE1 derivative is provided, which effectively targets an affected site, has excellent drug slow-release properties, and has reduced side effects. This PGE1-derivative-containing nanoparticle is a nanoparticle containing a prostaglandin E1 derivative represented by the following formula (1)
(wherein n denotes an integer of 1 to 12),
obtained by hydrophobicizing the prostaglandin E1 derivative with a metal ion, and reacting tne hydrophobicized prostaglandin E1 derivative with poly L-lactic acid or a poly(L-lactic acid/glycolic acid) copolymer and a poly DL- or L-lactic acid-polyethylene glycol block copolymer or a poly(DL- or L-lactic acid/glycolic acid)-polyethylene glycol block copolymer.
(wherein n denotes an integer of 1 to 12),
obtained by hydrophobicizing the prostaglandin E1 derivative with a metal ion, and reacting tne hydrophobicized prostaglandin E1 derivative with poly L-lactic acid or a poly(L-lactic acid/glycolic acid) copolymer and a poly DL- or L-lactic acid-polyethylene glycol block copolymer or a poly(DL- or L-lactic acid/glycolic acid)-polyethylene glycol block copolymer.
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