发明公开
EP2364306A1 Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors
有权
吡啶和衍生物作为磷酸二酯酶10抑制剂
- 专利标题： Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors
- 专利标题（中）： 吡啶和衍生物作为磷酸二酯酶10抑制剂
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申请号： EP09752706.3申请日： 2009-11-16
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公开(公告)号： EP2364306A1公开(公告)日： 2011-09-14
- 发明人: ALLEN, Jennifer R. , BISWAS, Kaustav , CHAVEZ, Frank, Jr. , CHEN, Ning , DEMORIN, Frenel Fils , FALSEY, James R. , FROHN, Mike , HARRINGTON, Paul , HORNE, Dan , HU, Essa , KALLER, Matthew R. , KUNZ, Roxanne , MONENSCHEIN, Holger , NGUYEN, Tom , PICKRELL, Alex , REICHELT, Andreas , RUMFELT, Shannon , RZASA, Rob , SHAM, Kelvin , YAO, Guomin
- 申请人： Amgen Inc.
- 申请人地址： One Amgen Center Drive Thousand Oaks, CA 91320-1799 US
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, CA 91320-1799 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US114595P 20081114; US166215P 20090402
- 国际公布： WO2010057126 20100520
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; C07D417/12 ; C07D471/04 ; C07D473/00 ; A61K31/4184 ; A61P25/18 ; A61P3/00
摘要：
Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
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