发明公开
- 专利标题： PROCESS FOR THE PREPARATION OF PIPERAZINE DERIVATIVES
- 专利标题（中）： 用于生产哌嗪衍生物
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申请号： EP09797147.7申请日： 2009-12-18
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公开(公告)号： EP2367807A1公开(公告)日： 2011-09-28
- 发明人: ÁGAINÉ CSONGOR, Éva , CZIBULE, László , SEBÖK, Ferenc , JUHÁSZ, Bálint , GALAMBOS, János , NÓGRÁDI, Katalin
- 申请人： Richter Gedeon Nyrt.
- 申请人地址： Gyömröi út 19-21. 1103 Budapest HU
- 专利权人： Richter Gedeon Nyrt.
- 当前专利权人： Richter Gedeon Nyrt.
- 当前专利权人地址： Gyömröi út 19-21. 1103 Budapest HU
- 代理机构： HOFFMANN EITLE
- 优先权： HU0800766 20081218
- 国际公布： WO2010070371 20100624
- 主分类号： C07D295/135
- IPC分类号： C07D295/135
摘要：
The invention relates to a process for the preparation of the trans
N-{ 4-{2-[4-(2,3- dichlorophenyl)-piperazine-1-yl]-ethyl}-cyclohexyl}-carbamide derivatives of formula (I) by reacting the compound of formula (III) with a carbamoylchloride of formula (II) which comprises carrying out the reaction in a mixture of a solvent and concentrated aqueous solution of an alkali hydroxide at a temperature between 40-100 °C in the presence of a phase transfer catalyst, separating the phases and washing the organic layer then removing the solvent and drying the compound of formula (I) obtained until its weight is constant.
N-{ 4-{2-[4-(2,3- dichlorophenyl)-piperazine-1-yl]-ethyl}-cyclohexyl}-carbamide derivatives of formula (I) by reacting the compound of formula (III) with a carbamoylchloride of formula (II) which comprises carrying out the reaction in a mixture of a solvent and concentrated aqueous solution of an alkali hydroxide at a temperature between 40-100 °C in the presence of a phase transfer catalyst, separating the phases and washing the organic layer then removing the solvent and drying the compound of formula (I) obtained until its weight is constant.
公开/授权文献
- EP2367807B1 PROCESS FOR THE PREPARATION OF PIPERAZINE DERIVATIVES 公开/授权日：2013-02-13
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