发明公开
- 专利标题： AMINOSÄUREESTER-PRODRUGS UND IHRE VERWENDUNG
- 专利标题（英）： Amino acid ester prodrugs and the use thereof
- 专利标题（中）： 氨基酸酯前药及其使用
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申请号： EP09760499.5申请日： 2009-12-03
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公开(公告)号： EP2379539A1公开(公告)日： 2011-10-26
- 发明人: MEIBOM, Daniel , LERCHEN, Hans-Georg , VAKALOPOULOS, Alexandros , ALBRECHT-KÜPPER, Barbara , NELL, Peter , KELDENICH, Jörg , ZIMMERMANN, Katja , KRENZ, Ursula
- 申请人： Bayer Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 优先权： DE102008062566 20081216
- 国际公布： WO2010072315 20100701
- 主分类号： C07D413/12
- IPC分类号： C07D413/12 ; A61K31/4439
摘要：
The invention relates to amino acid ester prodrug derivatives of 2-amino-6-({[2-(4-chlorphenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)4-(4-{[2,3-dihydroxypropyl]oxy}phenyl)pyridine- 3,5-dicarbonitriles of formula (I), where R
A is hydrogen or methyl, and R
PD is a group of the formulas (II) or (III), wherein # is the linking site having each O atom, to a method for the production thereof, to the use thereof for treating and/or preventing illnesses, and to the use thereof for producing pharmaceuticals for treating and/or preventing illnesses, particularly of cardiovascular diseases.
A is hydrogen or methyl, and R
PD is a group of the formulas (II) or (III), wherein # is the linking site having each O atom, to a method for the production thereof, to the use thereof for treating and/or preventing illnesses, and to the use thereof for producing pharmaceuticals for treating and/or preventing illnesses, particularly of cardiovascular diseases.
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