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1.发明公开HETEROCYCLISCHE-SUBSTITUIERTE 2-ACETAMIDO-5-ARYL-1,2,4-TRIAZOLONE UND DEREN VERWENDUNG 审中-公开杂环取代的2-乙酰氨基-5-芳基-1,2,4-三唑酮及其用途
公开(公告)号：EP2470530A1
公开(公告)日：2012-07-04
申请号：EP10745249.2
申请日：2010-08-24
发明人： FÜRSTNER, Chantal , KELDENICH, Jörg , KERN, Armin , DELBECK, Martina , KOLKHOF, Peter , KRETSCHMER, Axel , POOK, Elisabeth , SCHMECK, Carsten , TRÜBEL, Hubert
IPC分类号： C07D413/12 , C07D403/12 , C07D401/12 , A61K31/4245 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61P5/12 , A61P7/10 , A61P9/00
CPC分类号： C07D413/12 , C07D401/12 , C07D403/12
摘要： The present application relates to novel heterocyclic-substituted 1-carboylmethyl-3-aryl-1,2,4-triazol-5-ones, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular disorders. The compounds are vasopressin receptor antagonists.
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公开(公告)号：EP2379539A1
公开(公告)日：2011-10-26
申请号：EP09760499.5
申请日：2009-12-03
发明人： MEIBOM, Daniel , LERCHEN, Hans-Georg , VAKALOPOULOS, Alexandros , ALBRECHT-KÜPPER, Barbara , NELL, Peter , KELDENICH, Jörg , ZIMMERMANN, Katja , KRENZ, Ursula
IPC分类号： C07D413/12 , A61K31/4439
CPC分类号： C07D413/12 , A61K31/4439
摘要： The invention relates to amino acid ester prodrug derivatives of 2-amino-6-({[2-(4-chlorphenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)4-(4-{[2,3-dihydroxypropyl]oxy}phenyl)pyridine- 3,5-dicarbonitriles of formula (I), where R
A is hydrogen or methyl, and R
PD is a group of the formulas (II) or (III), wherein # is the linking site having each O atom, to a method for the production thereof, to the use thereof for treating and/or preventing illnesses, and to the use thereof for producing pharmaceuticals for treating and/or preventing illnesses, particularly of cardiovascular diseases.-
3.发明公开Substituierte 2-acetamido-5-aryl-1,2,4-triazolone und deren verwendung 有权取代的2-乙酰氨基-5-芳基-1,2,4-三唑酮和deren Verwendung
公开(公告)号：EP2408751A1
公开(公告)日：2012-01-25
申请号：EP10709419.5
申请日：2010-03-12
发明人： BRÜGGEMEIER, Ulf , FÜRSTNER, Chantal , GEISS, Volker , KELDENICH, Jörg , KERN, Armin , DELBECK, Martina , KOLKHOF, Peter , KRETSCHMER, Axel , POOK, Elisabeth , SCHMECK, Carsten , TRÜBEL, Hubert
IPC分类号： C07D233/70 , C07D249/12 , C07D409/04 , C07D413/12 , A61K31/4166 , A61K31/4196 , A61K31/422 , A61P9/00
CPC分类号： C07D233/70 , A61K9/0095 , A61K9/2054 , A61K31/4166 , A61K31/4196 , A61K31/422 , A61K45/06 , C07D249/12 , C07D409/04 , C07D413/12 , A61K2300/00
摘要： The invention relates to novel, substituted 2-acetamido-5-aryl-1,2,4-triazolones, to methods for producing the same, to the use thereof either alone or in combination in the treatment and/or prevention of diseases and to their use for producing drugs for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本申请涉及新的取代的2-乙酰氨基-5-芳基-1,2,4-三唑酮，用于制备它们的方法，单独使用或组合用于治疗和/或预防疾病，以及它们 用于生产用于治疗和/或预防疾病的药物，更具体地用于治疗和/或预防心血管疾病。
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公开(公告)号：EP2379540A1
公开(公告)日：2011-10-26
申请号：EP09764200.3
申请日：2009-12-03
发明人： LERCHEN, Hans-Georg , MEIBOM, Daniel , VAKALOPOULOS, Alexandros , ALBRECHT-KÜPPER, Barbara , KELDENICH, Jörg , ZIMMERMANN, Katja , NELL, Peter , KRENZ, Ursula
IPC分类号： C07D413/12 , A61K31/4439 , C07K5/062 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078
CPC分类号： C07D413/12 , A61K31/4439 , C07K5/0202 , C07K5/0205 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06086 , C07K5/06104 , C07K5/06113 , C07K5/06147 , C07K5/06165
摘要： The invention relates to dipeptide-like prodrug derivates of the formula (I), where R
PD is a group of the formula (Ia), (Ib), (Ic) or (Id), wherein # means the linking site to each O atom, to a method for the production thereof, to the use thereof for treating and/or preventing illnesses, and to the use thereof for producing pharmaceuticals for treating and/or preventing illnesses, particularly cardiovascular diseases.-
5.发明授权SUBSTITUIERTE PYRROLO[2, 3-B]- UND PYRAZOLO[3, 4-B]PYRIDINE ALS ADENOSIN REZEPTOR LIGANDEN 有权取代的吡咯并[2,3-B] - 和吡唑并[3,4-b]吡啶ALS腺苷受体配体
公开(公告)号：EP2235011B1
公开(公告)日：2012-01-25
申请号：EP08864918.1
申请日：2008-12-09
发明人： NELL, Peter , VAKALOPOULOS, Alexandros , SÜSSMEIER, Frank , ALBRECHT-KÜPPER, Barbara , ZIMMERMANN, Katja , KELDENICH, Jörg , MEIBOM, Daniel
IPC分类号： C07D471/04 , A61P9/04 , A61P9/10 , A61P3/10 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to novel substituted pyrrolopyridine, pyrazolopyridine and isoxazolopyridine derivatives, to methods for producing the same, to the use thereof in the treatment and/or prevention of diseases and to their use in the production of drugs for use in the treatment and/or prevention of diseases, preferably in the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：EP2185550B1
公开(公告)日：2011-11-02
申请号：EP08774012.2
申请日：2008-07-17
发明人： NELL, Peter , HÜBSCH, Walter , ALBRECHT-KÜPPER, Barbara , KELDENICH, Jörg , VAKALOPOULOS, Alexandros , SÜSSMEIER, Frank , ZIMMERMANN, Katja , LANG, Dieter , MEIBOM, Daniel
IPC分类号： C07D413/12 , C07D413/14 , C07D419/14 , A61K31/40 , A61P9/06
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, a method for the production thereof, the use thereof for the treatment and/or prophylaxis of diseases and the use thereof for the production of drugs for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
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7.发明授权1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS 有权1,4- DIARYLDIHYDROPYRIMIDIN -2-酮及其用作人中性粒细胞弹性的抑制剂
公开(公告)号：EP1723121B1
公开(公告)日：2012-07-25
申请号：EP05707386.8
申请日：2005-02-15
发明人： GIELEN-HAERTWIG, Heike , ALBRECHT, Barbara , KELDENICH, Jörg , LI, Volkhart , PERNERSTORFER, Josef , SCHLEMMER, Karl-Heinz , TELAN, Leila
IPC分类号： C07D239/22 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/06 , C07D417/06 , C07F9/6512 , A61K31/505 , A61K31/506 , A61K31/662 , A61P11/00
CPC分类号： C07D239/22 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/06 , C07D417/06
摘要： The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
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8.发明授权SUBSTITUIERTE ARYLIMIDAZ0L0NE UND -TRIAZ0L0NE ALS INHIBITOREN DER VASOPRESSIN-REZEPTOREN 有权取代ARYLIMIDAZ0L0NE和-TRIAZ0L0NE加压素受体的抑制剂
公开(公告)号：EP2027096B1
公开(公告)日：2012-05-23
申请号：EP07725514.9
申请日：2007-05-23
发明人： MEIER, Heinrich , BENDER, Eckhard , BRÜGGEMEIER, Ulf , FLAMME, Ingo , KARTHAUS, Dagmar , KOLKHOF, Peter , MEIBOM, Daniel , SCHNEIDER, Dirk , VOEHRINGER, Verena , FÜRSTNER, Chantal , KELDENICH, Jörg , LANG, Dieter , POOK, Elisabeth , SCHMECK, Carsten
IPC分类号： C07D233/70 , C07D249/12 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/14 , A61K31/4166 , A61K31/4178 , A61K31/4196 , A61P9/00
CPC分类号： C07D249/12 , C07D233/70 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/14
摘要： The present application relates to new, substituted 4-Arylimidazol-2-one and 5-Aryl-l,2,4-triazolone, a method for their production, their use alone or in combination in treating and/or preventing diseases, as well as their use in producing medicaments for treating and/or preventing diseases, in particular cardiovascular diseases.
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