发明公开
- 专利标题： PROCEDES POUR DETERMINER LA SUSCEPTIBILITE A CONTRACTER UNE INFECTION NOSOCOMIALE CHEZ UN PATIENT ET POUR ETABLIR UN PRONOSTIC D'EVOLUTION D'UN SYNDROME SEPTIQUE
- 专利标题（英）： Methods for determining the likelihood of a patient contracting a nosocomial infection and for determining the prognosis of the course of a septic syndrome
- 专利标题（中）： 法确定实体的易感性FOR化粪池综合征医院感染及前景发展
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申请号： EP10707312.4申请日： 2010-01-18
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公开(公告)号： EP2379752A1公开(公告)日： 2011-10-26
- 发明人: CAZALIS, Marie-Angélique , LEPAPE, Alain , MONNERET, Guillaume , MOUGIN, Bruno , PACHOT, Alexandre
- 申请人： Biomérieux S.A. , Hospices Civils de Lyon
- 申请人地址： Chemin de l'Orme 69280 Marcy L'Etoile FR
- 专利权人： Biomérieux S.A.,Hospices Civils de Lyon
- 当前专利权人： Biomérieux S.A.,Hospices Civils de Lyon
- 当前专利权人地址： Chemin de l'Orme 69280 Marcy L'Etoile FR
- 优先权： FR0950306 20090119; FR0950305 20090119
- 国际公布： WO2010082004 20100722
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
The present invention relates to a method for determining the likelihood of a patient contracting a nosocomial infection and to a method for determining the prognosis of the course of a septic syndrome in a patient, according to which: a. a biological sample is obtained from the patient and biological material is extracted from the biological sample; b. at least one specific reagent is obtained from an expression construct of at least one target gene selected from target genes S100A9 and S100A8; c. the expression of at least one of the target genes S100A9 and S100A8 is determined, an overexpression relative to a predetermined threshold value indicating the likelihood of contracting a nosocomial infection as well as indicating a poor prognosis of the course of a septic syndrome.
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