发明公开
EP2385034A2 Process for the preparation of 1-nitro-4-oxobutanylamides
有权
Verfahren zur Synthese von 1-Nitro-4-oxobutanylamiden
- 专利标题： Process for the preparation of 1-nitro-4-oxobutanylamides
- 专利标题（中）： Verfahren zur Synthese von 1-Nitro-4-oxobutanylamiden
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申请号： EP11164806.9申请日： 2011-05-04
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公开(公告)号： EP2385034A2公开(公告)日： 2011-11-09
- 发明人: Rehak, Juraj, Ing., PhD. , Lu, Gui, Prof. , Durmis, Julius, Ing., PhD. , Weng, Jiang , Brath, Henrich, Ing. , Li, Yong-Bo , Hutka, Martin, RNDr., PhD. , Toma, Stefan, RNDr., Prof. , Latika, Attila
- 申请人： Synkola, s.r.o.
- 申请人地址： Mlynska dolina CH-2 842 15 Bratislava SK
- 专利权人： Synkola, s.r.o.
- 当前专利权人： Synkola, s.r.o.
- 当前专利权人地址： Mlynska dolina CH-2 842 15 Bratislava SK
- 代理机构： Bachrata, Magdaléna
- 优先权： SK50132010 20100505
- 主分类号： C07C231/02
- IPC分类号： C07C231/02 ; C07C231/12 ; C07C233/13 ; C07C233/25 ; C07C233/31 ; C07C233/75
摘要：
It is disclosed a process for the preparation of 1-nitro-4-oxobutanylamides of general formula Ia and Ib
or opposite enantiomers thereof,
wherein R1 is H, alyl, alkyloxycarbonyl, arylalkyloxycarbonyl with a number of carbon atoms up to 24, or the same as in R2, R2 represents alkyl, cycloalkyl or phenylalkyl with up to 24 carbon atoms, and R3 represents alkyl, alkylphenyl, phenylalkyl or phenyl, substituted phenyl, alkoxyphenylalkyl with up to 24 carbon atoms, by the reaction of the
with 2-nitroethenylamides of general formula IIIa and/or IIIb,
where R1, R2 and R3 are as cited above,
in the presence of organic catalysts and co-catalysts in organic solvent, water, in solution of inorganic salts in water or in the mixture of organic solvents and water or in the mixture of solutions of inorganic salts in water and organic solvents at the temperature between -20 and +50 °C.
or opposite enantiomers thereof,
wherein R1 is H, alyl, alkyloxycarbonyl, arylalkyloxycarbonyl with a number of carbon atoms up to 24, or the same as in R2, R2 represents alkyl, cycloalkyl or phenylalkyl with up to 24 carbon atoms, and R3 represents alkyl, alkylphenyl, phenylalkyl or phenyl, substituted phenyl, alkoxyphenylalkyl with up to 24 carbon atoms, by the reaction of the
with 2-nitroethenylamides of general formula IIIa and/or IIIb,
where R1, R2 and R3 are as cited above,
in the presence of organic catalysts and co-catalysts in organic solvent, water, in solution of inorganic salts in water or in the mixture of organic solvents and water or in the mixture of solutions of inorganic salts in water and organic solvents at the temperature between -20 and +50 °C.
公开/授权文献
- EP2385034B1 Process for the preparation of 1-nitro-4-oxobutanylamides 公开/授权日：2015-12-02
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