公开(公告)号：EP2385034B1

公开(公告)日：2015-12-02

申请号：EP11164806.9

申请日：2011-05-04

申请人： Synkola, s.r.o.

发明人： Rehak, Juraj, Ing., PhD. ,  Lu, Gui, Prof. ,  Durmis, Julius, Ing., PhD. ,  Weng, Jiang ,  Brath, Henrich, Ing. ,  Li, Yong-Bo ,  Hutka, Martin, RNDr., PhD. ,  Toma, Stefan, RNDr., Prof. ,  Latika, Attila

IPC分类号： C07C231/12 ,  C07C233/13 ,  C07C233/31 ,  C07C233/75 ,  C07C271/48

CPC分类号： C07C233/31 ,  C07B2200/07 ,  C07B2200/09 ,  C07C231/12 ,  C07C233/13 ,  C07C271/48

公开(公告)号：EP2385034A3

公开(公告)日：2012-07-18

申请号：EP11164806.9

申请日：2011-05-04

申请人： Synkola, s.r.o.

发明人： Rehak, Juraj, Ing., PhD. ,  Lu, Gui, Prof. ,  Durmis, Julius, Ing., PhD. ,  Weng, Jiang ,  Brath, Henrich, Ing. ,  Li, Yong-Bo ,  Hutka, Martin, RNDr., PhD. ,  Toma, Stefan, RNDr., Prof. ,  Latika, Attila

IPC分类号： C07C231/02 ,  C07C231/12 ,  C07C233/13 ,  C07C233/25 ,  C07C233/31 ,  C07C233/75

CPC分类号： C07C233/31 ,  C07B2200/07 ,  C07B2200/09 ,  C07C231/12 ,  C07C233/13 ,  C07C271/48

摘要： It is disclosed a process for the preparation of 1-nitro-4-oxobutanylamides of general formula Ia and Ib

or opposite enantiomers thereof,
wherein R1 is H, alyl, alkyloxycarbonyl, arylalkyloxycarbonyl with a number of carbon atoms up to 24, or the same as in R2, R2 represents alkyl, cycloalkyl or phenylalkyl with up to 24 carbon atoms, and R3 represents alkyl, alkylphenyl, phenylalkyl or phenyl, substituted phenyl, alkoxyphenylalkyl with up to 24 carbon atoms, by the reaction of the

with 2-nitroethenylamides of general formula IIIa and/or IIIb,

where R1, R2 and R3 are as cited above,
in the presence of organic catalysts and co-catalysts in organic solvent, water, in solution of inorganic salts in water or in the mixture of organic solvents and water or in the mixture of solutions of inorganic salts in water and organic solvents at the temperature between -20 and +50 °C.

公开(公告)号：EP2385034A2

公开(公告)日：2011-11-09

申请号：EP11164806.9

申请日：2011-05-04

申请人： Synkola, s.r.o.

发明人： Rehak, Juraj, Ing., PhD. ,  Lu, Gui, Prof. ,  Durmis, Julius, Ing., PhD. ,  Weng, Jiang ,  Brath, Henrich, Ing. ,  Li, Yong-Bo ,  Hutka, Martin, RNDr., PhD. ,  Toma, Stefan, RNDr., Prof. ,  Latika, Attila

IPC分类号： C07C231/02 ,  C07C231/12 ,  C07C233/13 ,  C07C233/25 ,  C07C233/31 ,  C07C233/75

CPC分类号： C07C233/31 ,  C07B2200/07 ,  C07B2200/09 ,  C07C231/12 ,  C07C233/13 ,  C07C271/48

摘要： It is disclosed a process for the preparation of 1-nitro-4-oxobutanylamides of general formula Ia and Ib

or opposite enantiomers thereof,
wherein R1 is H, alyl, alkyloxycarbonyl, arylalkyloxycarbonyl with a number of carbon atoms up to 24, or the same as in R2, R2 represents alkyl, cycloalkyl or phenylalkyl with up to 24 carbon atoms, and R3 represents alkyl, alkylphenyl, phenylalkyl or phenyl, substituted phenyl, alkoxyphenylalkyl with up to 24 carbon atoms, by the reaction of the

with 2-nitroethenylamides of general formula IIIa and/or IIIb,

where R1, R2 and R3 are as cited above,
in the presence of organic catalysts and co-catalysts in organic solvent, water, in solution of inorganic salts in water or in the mixture of organic solvents and water or in the mixture of solutions of inorganic salts in water and organic solvents at the temperature between -20 and +50 °C.

摘要翻译： 公开了制备通式Ia和Ib的1-硝基-4-氧代丁酰基酰胺或其相对的对映异构体的方法，其中R 1是H，烯丙基，烷氧基羰基，多至24个碳原子的芳基烷氧基羰基，或相同 如在R2中，R2代表具有至多24个碳原子的烷基，环烷基或苯基烷基，R3代表烷基，烷基苯基，苯基烷基或苯基，取代的苯基，具有至多24个碳原子的烷氧基苯基烷基，通过2-硝基苯基酰胺与 通式IIIa和/或IIIb，其中R 1，R 2和R 3如上所述，在有机催化剂和助催化剂存在下，在有机溶剂，水，无机盐在水中的溶液或有机溶剂和 水或无机盐在水和有机溶剂中的溶液的混合物，温度为-20至+50℃。