- 专利标题： Human anti-B7RP1 neutralizing antibodies
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申请号： EP11004890.7申请日： 2006-07-18
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公开(公告)号： EP2388276A2公开(公告)日： 2011-11-23
- 发明人: Siu, Gerald , Shen, Wenyan , Yoshinaga, Steven Kiyoshi , Huang, Haichun
- 申请人： Amgen, Inc , Medarex, Inc.
- 申请人地址： One Amgen Center Drive Thousand Oaks, CA 91320-1799 US
- 专利权人： Amgen, Inc,Medarex, Inc.
- 当前专利权人： Amgen, Inc,Medarex, Inc.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, CA 91320-1799 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser
- 优先权： US700265P 20050718
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61P37/00 ; A61P11/06 ; A61K39/395 ; G01N33/68 ; G01N33/577 ; C12N15/13 ; C12N5/10
摘要：
This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
公开/授权文献
- EP2388276A3 Human anti-B7RP1 neutralizing antibodies 公开/授权日：2013-11-27
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