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公开(公告)号：EP2388276A3
公开(公告)日：2013-11-27
申请号：EP11004890.7
申请日：2006-07-18
申请人： Amgen, Inc , Medarex, Inc.
IPC分类号： C07K16/28 , A61P37/00 , A61P11/06 , A61K39/395 , G01N33/68 , G01N33/577 , C12N15/13 , C12N5/10 , C07K16/18
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
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公开(公告)号：EP2388277A2
公开(公告)日：2011-11-23
申请号：EP11004891.5
申请日：2006-07-18
申请人： Amgen, Inc , Medarex, Inc.
IPC分类号： C07K16/28 , A61P37/00 , A61P11/06 , A61K39/395 , G01N33/68 , G01N33/577 , C12N15/13 , C12N5/10
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
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公开(公告)号：EP2388277A3
公开(公告)日：2013-03-20
申请号：EP11004891.5
申请日：2006-07-18
申请人： Amgen, Inc , Medarex, Inc.
IPC分类号： C07K16/28 , A61P37/00 , A61P11/06 , A61K39/395 , G01N33/68 , G01N33/577 , C12N15/13 , C12N5/10
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
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公开(公告)号：EP2397497A2
公开(公告)日：2011-12-21
申请号：EP11004892.3
申请日：2006-07-18
申请人： Amgen, Inc , Medarex, Inc.
IPC分类号： C07K16/28 , A61P37/00 , A61P11/06 , A61K39/395 , G01N33/68 , G01N33/577 , C12N15/13 , C12N5/10
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
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5.发明公开Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors 审中-公开Menschliche抗NGF-neutralisierendeAntikörperALS selektive NGF-Pfadhemmer
公开(公告)号：EP2364728A1
公开(公告)日：2011-09-14
申请号：EP10011652.4
申请日：2004-07-15
申请人： Amgen, Inc , Medarex, Inc.
发明人： Wild, Kenneth D., Jr. , Treanor, James J.,S. , Huang, Haichun , Inoue, Heather , Zhang, Tie, J. , Martin, Frank
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/48 , G01N2800/2842
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
摘要翻译： 本发明提供了与相互作用或与之结合人神经生长因子（NGF）和从而中NGF的功能的抗体。 本发明还提供所述抗体和方法的药物组合物中和NGF的功能，特别是用于通过施用药学有效量的抗NGF抗体的NGF治疗相关病症（例如慢性疼痛）。 还提供了使用抗NGF抗体检测样品中的NGF的量的方法。
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公开(公告)号：EP2213685B1
公开(公告)日：2013-11-27
申请号：EP10003365.3
申请日：2003-09-05
申请人： Amgen Inc. , Medarex, Inc.
发明人： Huang, Haichun , Varnum, Brian , Vezina, Chris , Witte, Alison , Qian, Xueming , Martin, Francis , Elliott, Gary
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
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公开(公告)号：EP2397498A2
公开(公告)日：2011-12-21
申请号：EP11004893.1
申请日：2006-07-18
申请人： Amgen, Inc , Medarex, Inc.
IPC分类号： C07K16/28 , A61P37/00 , A61P11/06 , A61K39/395 , G01N33/68 , G01N33/577 , C12N15/13 , C12N5/10
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
摘要翻译： 本发明提供了与人B7相关蛋白-1（B7RP1）相互作用或与之结合的抗体以及结合并中和B7RP1功能的抗体。 本发明还提供了所述抗体的药物组合物和中和B7RP1功能的方法，特别是通过施用药学有效量的抗B7RPI抗体来治疗免疫疾病（例如，不适当的免疫应答）。 还提供了使用抗B7RPI抗体检测样品中B7RP1的量的方法。
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公开(公告)号：EP2397496A2
公开(公告)日：2011-12-21
申请号：EP11004885.7
申请日：2006-07-18
申请人： Amgen, Inc , Medarex, Inc.
IPC分类号： C07K16/28 , A61P37/00 , A61P11/06 , A61K39/395 , G01N33/68 , G01N33/577 , C12N15/13 , C12N5/10
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
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公开(公告)号：EP2397499A3
公开(公告)日：2013-12-25
申请号：EP11004894.9
申请日：2006-07-18
申请人： Amgen, Inc , Medarex, Inc.
IPC分类号： C07K16/28 , A61P37/00 , A61P11/06 , A61K39/395 , G01N33/68 , G01N33/577 , C12N15/13 , C12N5/10 , C07K16/18
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
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公开(公告)号：EP2397498A3
公开(公告)日：2013-11-27
申请号：EP11004893.1
申请日：2006-07-18
申请人： Amgen, Inc , Medarex, Inc.
IPC分类号： C07K16/28 , A61P37/00 , A61P11/06 , A61K39/395 , G01N33/68 , G01N33/577 , C12N15/13 , C12N5/10 , C07K16/18
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPI antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPI antibodies are also provided.
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