发明公开
EP2389390A2 MEANS AND METHODS FOR MODULATING NOTCH3 PROTEIN EXPRESSION AND/OR THE CODING REGION OF NOTCH3; COMPOSITIONS AND USE THEREOF IN THE TREATMENT OF CADASIL
审中-公开
手段和一种用于调节NOTCH3蛋白的表达和/或编码NOTCH3，组合物及其使用区域CADASIL的治疗
- 专利标题： MEANS AND METHODS FOR MODULATING NOTCH3 PROTEIN EXPRESSION AND/OR THE CODING REGION OF NOTCH3; COMPOSITIONS AND USE THEREOF IN THE TREATMENT OF CADASIL
- 专利标题（中）： 手段和一种用于调节NOTCH3蛋白的表达和/或编码NOTCH3，组合物及其使用区域CADASIL的治疗
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申请号： EP10702361.6申请日： 2010-01-26
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公开(公告)号： EP2389390A2公开(公告)日： 2011-11-30
- 发明人: LESNIK OBERSTEIN, Saskia Anne-Marie Jenny , VAN OMMEN, Garrit-Jan Boudewijn , RUS, Adriana Marie , DAUWERSE, Johannes Gregorius
- 申请人： Academisch Ziekenhuis Leiden h.o.d.n. Leids Universitair Medisch Centrum
- 申请人地址： Albinusdreef 2 2333 ZA Leiden NL
- 专利权人： Academisch Ziekenhuis Leiden h.o.d.n. Leids Universitair Medisch Centrum
- 当前专利权人： Academisch Ziekenhuis Leiden h.o.d.n. Leids Universitair Medisch Centrum
- 当前专利权人地址： Albinusdreef 2 2333 ZA Leiden NL
- 代理机构： Jansen, Cornelis Marinus
- 优先权： EP09151326 20090126
- 国际公布： WO2010085151 20100729
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; C12N15/11
摘要：
The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 m RNA or pre-m RNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 m RNA or pre-m RNA.
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