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1.发明公开RECOMBINANT AAV-CRUMBS HOMOLOGUE COMPOSITION AND METHODS FOR TREATING LCA-8 AND PROGRESSIVE RP 审中-公开重组AAV-CRUMBS同源组合物和治疗LCA-8和进展性RP的方法
公开(公告)号：EP3030665A1
公开(公告)日：2016-06-15
申请号：EP14761426.7
申请日：2014-08-05
CPC分类号： C07K14/705 , A01K67/0276 , A01K2217/075 , A01K2217/203 , A01K2227/105 , A01K2267/03 , A61K35/76 , A61K48/005 , C07K14/47 , C12N15/86 , C12N2750/14132 , C12N2750/14143 , C12N2750/14171 , C12N2830/48
摘要： The present invention relates to a Crumbs homologue (CRB) therapeutic for use as a medicament or in a method of treatment or prophylaxis, for example in the treatment or prophylaxis of a retinal disorder due to mutations in the Crumbs homologue-1 (CRB1) gene, such as Leber's congenital amaurosis 8 (LCA8) or retinitis pigmentosa 12 (RP12). In particular, the present invention relates to a recombinant viral vector comprising CRB2 or modified non-toxic forms of either CRB1 or CRB3 that resemble CRB2.
摘要翻译： 本发明涉及用作药物或在治疗或预防方法中使用的面包屑同系物（CRB）治疗剂，例如治疗或预防由于Crumbs同系物-1（CRB1）基因突变引起的视网膜病症， 例如莱伯氏先天性黑蒙8（LCA8）或色素性视网膜炎12（RP12）。特别地，本发明涉及包含CRB2或类似CRB2的CRB1或CRB3的修饰的无毒形式的重组病毒载体。
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公开(公告)号：EP2812691A1
公开(公告)日：2014-12-17
申请号：EP13710587.0
申请日：2013-02-06
申请人： HQ Medical (Netherlands) B.V. , Publiekrechtelijke rechtspersoon Academisch Ziekenhuis Leiden h.o.d.n. Leids Universitair Medisch Centrum
IPC分类号： G01N33/50
摘要： The present invention relates to a method for detecting cell death using a luminescent compound; to the luminescent compounds for particular uses; to a kit comprising compounds and to a protein. The method is applicable for detecting cell death, essentially regardless of the mechanism through which cell death occurred or is occurring and is therefore not limited e.g. to detecting cell death resulting from only one mechanism selected from apoptosis and necrosis.
摘要翻译： 本发明涉及使用发光化合物检测细胞死亡的方法; 涉及用于特定用途的发光化合物; 涉及包含所述化合物和蛋白质的试剂盒。 该方法适用于检测细胞死亡，基本上不管细胞死亡发生或正在发生的机制如何，因此不限于例如细胞死亡。 检测仅由选自凋亡和坏死的一种机制引起的细胞死亡。
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公开(公告)号：EP2201027A2
公开(公告)日：2010-06-30
申请号：EP08839407.7
申请日：2008-10-16
CPC分类号： C07K14/005 , A61K35/13 , A61K2039/525 , A61K2039/5256 , C07K2319/21 , C12N7/00 , C12N2720/12222 , C12N2720/12252 , C12N2740/15043 , C12N2810/00 , C12N2810/40
摘要： The present invention provides a reverse genetics system for viruses belonging to the Reoviridae (i.e. Reoviruses), various uses thereof, genetically modified Reoviruses, Reovirus selection/production and propagation systems, medicaments and vaccines.
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公开(公告)号：EP4327819A3
公开(公告)日：2024-05-29
申请号：EP23209249.4
申请日：2018-06-28
IPC分类号： C07K14/725 , C07K14/47 , A61K48/00 , A61K39/00
CPC分类号： C07K14/7051 , C07K14/4748 , C12N2740/1004320130101 , A61K39/464838 , A61K39/4611
摘要： Novel nucleic acid sequences, vectors, modified cells, peptides and pharmaceutical compositions are provided that are useful in the treatment of human subjects having a ΔNPM 1 positive haematological malignancy. Corresponding methods and uses are also provided.
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5.发明公开
公开(公告)号：EP4219544A1
公开(公告)日：2023-08-02
申请号：EP23150885.4
申请日：2016-03-09
摘要： The technology relates in part to compositions and methods for inducing an immune response against the Preferentially Expressed Antigen of Melanoma (FRAME). Provided are methods for treating hyperproliferative diseases by inducing an immune response against PRAME antigen; the immune response may be induced by specifically targeting PRAME-expressing cells using T cell receptors directed against PRAME.
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6.发明授权INDUCTION OF ANTI-TUMOR CTL IMMUNITY THROUGH IN VIVO TRIGGERING OF 4-1BB AND/OR CD40 有权抗肿瘤CTL免疫的THROUGH 4-1BB和/或CD40的激活体内诱导
公开(公告)号：EP1490407B1
公开(公告)日：2007-05-16
申请号：EP03745713.2
申请日：2003-04-04
IPC分类号： C07K16/28 , A61K39/395 , C07K14/025 , A61K39/12
CPC分类号： C07K16/2878 , A61K2039/505
摘要： Disclosed is a method and composition for treating tumors or infectious diseases, wherein the composition comprises an agonistic anti-CD40 antibody or a fragment thereof, and/or an agonistic anti-4-1BB antibody or a fragment thereof. The agonistic antibody molecules include fragments like Fab, (Fab')2 and Fv. The methods and compositions may further comprise polypeptides or mucleic acid sequences having or encoding a class 1 MHC or class II MHC-restricted T cell epitope.
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公开(公告)号：EP4327819A2
公开(公告)日：2024-02-28
申请号：EP23209249.4
申请日：2018-06-28
IPC分类号： A61K39/00
摘要： Novel nucleic acid sequences, vectors, modified cells, peptides and pharmaceutical compositions are provided that are useful in the treatment of human subjects having a ΔNPM 1 positive haematological malignancy. Corresponding methods and uses are also provided.
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8.发明公开
公开(公告)号：EP3849466A1
公开(公告)日：2021-07-21
申请号：EP19782789.2
申请日：2019-09-11
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公开(公告)号：EP2029220B1
公开(公告)日：2013-01-02
申请号：EP07747461.7
申请日：2007-05-23
发明人： PELGER, Robertus, Coenraad, Maria , OUWERKERK, Theodorus, Johannes , VOORHAM - VAN DER ZALM, Pieternella, Johanna
IPC分类号： A61N1/05 , A63B23/20 , A61B5/0488
CPC分类号： A61N1/36007 , A61B5/0488 , A61B5/04882 , A61B5/486 , A61H19/00 , A61H19/44 , A61H21/00 , A61H2205/085 , A61H2205/086 , A61H2230/605 , A61N1/0509 , A61N1/0512 , A61N1/0524 , A61N1/08 , A63B23/20
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10.发明公开MEANS AND METHODS FOR MODULATING NOTCH3 PROTEIN EXPRESSION AND/OR THE CODING REGION OF NOTCH3; COMPOSITIONS AND USE THEREOF IN THE TREATMENT OF CADASIL 审中-公开手段和一种用于调节NOTCH3蛋白的表达和/或编码NOTCH3，组合物及其使用区域CADASIL的治疗
公开(公告)号：EP2389390A2
公开(公告)日：2011-11-30
申请号：EP10702361.6
申请日：2010-01-26
发明人： LESNIK OBERSTEIN, Saskia Anne-Marie Jenny , VAN OMMEN, Garrit-Jan Boudewijn , RUS, Adriana Marie , DAUWERSE, Johannes Gregorius
IPC分类号： C07K14/705 , C12N15/11
摘要： The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 m RNA or pre-m RNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 m RNA or pre-m RNA.
摘要翻译： 其他中，本发明提供的手段和方法，用于调制NOTCH3表达和/或蛋白编码域。 在一个方面，本发明提供了一种用于至少减小到升高水平NOTCH3蛋白在一个NOTCH3表达细胞或其所述方法紧邻包含特异性针对NOTCH3米RNA或预米RNA的反义寡核苷酸提供所述细胞与 从而降低制备所述NOTCH3蛋白或由此改变在说NOTCH3米RNA或预米RNA的蛋白质编码区。
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