发明公开
EP2399924A2 Nuclease resistant double-stranded ribonucleic acid
有权
NukleaseresistentedoppelsträngigeRibonukleinsäure
- 专利标题: Nuclease resistant double-stranded ribonucleic acid
- 专利标题(中): NukleaseresistentedoppelsträngigeRibonukleinsäure
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申请号: EP11007734.4申请日: 2005-05-27
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公开(公告)号: EP2399924A2公开(公告)日: 2011-12-28
- 发明人: Vornlocher, Hans-Peter , Hadwiger, Philipp , Zimmermann, Tracy Stage , Manoharan, Muthiah , Rajeev, Kallanthottathil G. , Roehl, Ingo , Akinc, Akin
- 申请人: Alnylam Pharmaceuticals, Inc.
- 申请人地址: 300 Third Street Cambridge, MA 02142 US
- 专利权人: Alnylam Pharmaceuticals, Inc.
- 当前专利权人: Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址: 300 Third Street Cambridge, MA 02142 US
- 代理机构: Vossius & Partner
- 优先权: US574744P 20040527; US607850P 20040907; US607790P 20040908; US634860P 20041209
- 主分类号: C07H21/02
- IPC分类号: C07H21/02 ; C12N15/11
摘要:
This invention relates to methods of making modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids.
公开/授权文献
- EP2399924B1 Nuclease resistant double-stranded ribonucleic acid 公开/授权日:2015-01-28
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