发明公开
- 专利标题： NOVEL MONOCLONAL ANTIBODY, AND USE THEREOF
- 专利标题（中）： 维也纳戴蒙公司的诺基亚MONOKLONALERANTIKÖRPER
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申请号： EP10743590.1申请日： 2010-02-20
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公开(公告)号： EP2399934A1公开(公告)日： 2011-12-28
- 发明人: HAMAKUBO, Takao , MOCHIZUKI, Yasuhiro , ABURATANI, Hiroyuki , IWANARI, Hiroko , NIWA, Shunsuke , NAKADA, Yoshiko
- 申请人： The University of Tokyo , Perseus Proteomics Inc.
- 申请人地址： 3-1, Hongo 7-chome Bunkyo-Ku Tokyo 113-8654 JP
- 专利权人： The University of Tokyo,Perseus Proteomics Inc.
- 当前专利权人： The University of Tokyo,Perseus Proteomics Inc.
- 当前专利权人地址： 3-1, Hongo 7-chome Bunkyo-Ku Tokyo 113-8654 JP
- 代理机构： Banse & Steglich
- 优先权： JP2009037341 20090220; JP2009153853 20090629
- 国际公布： WO2010095461 20100826
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/395 ; A61K49/00 ; A61K51/00 ; A61P35/00 ; C12N5/10 ; C12N15/02 ; C12P21/08
摘要：
[Theme] To provide a monoclonal antibody against human GPR87. Also, to provide a novel means for diagnosing or treating a malignant tumor.
[Solution means] Monoclonal antibodies against human GPR87 are provided. The antibodies can recognize human GPR87, which is expressed on a cell membrane while retaining a three-dimensional structure, and can recognize GPR87, which is expressed in a cell endogenously with an epitope being present in an extracellular domain of full-length human GPR87. The antibodies are thus useful in biochemical analysis, etc., of GPR87, useful in immunohistological diagnosis, etc., of squamous cell carcinoma, and also potentially useful in PET diagnosis, antibodies for treatment, etc., of squamous cell carcinoma.
[Solution means] Monoclonal antibodies against human GPR87 are provided. The antibodies can recognize human GPR87, which is expressed on a cell membrane while retaining a three-dimensional structure, and can recognize GPR87, which is expressed in a cell endogenously with an epitope being present in an extracellular domain of full-length human GPR87. The antibodies are thus useful in biochemical analysis, etc., of GPR87, useful in immunohistological diagnosis, etc., of squamous cell carcinoma, and also potentially useful in PET diagnosis, antibodies for treatment, etc., of squamous cell carcinoma.
公开/授权文献
- EP2399934B1 NOVEL MONOCLONAL ANTIBODY, AND USE THEREOF 公开/授权日：2017-09-06
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