公开(公告)号：EP4480507A1

公开(公告)日：2024-12-25

申请号：EP22927052.5

申请日：2022-02-16

Applicant: Mochida Pharmaceutical Co., Ltd. ,  The University of Tokyo

Inventor： ITO Taichi ,  CHANDEL Arvind Kumar Singh ,  ISAJI Mitsuko

IPC: A61L24/08 ,  C08B37/02 ,  C08B37/04 ,  C08B37/08

Abstract: [Problem] To provide an additional use of a polysaccharide derivative such as a tissue adhesive material.
[Solution] According to some embodiments, a tissue adhesive material is provided, which is intended to be used for a hard and thick tissue and/or a connective tissue and comprises a polysaccharide derivative having such a structure that a group represented by formula (A) is introduced in an acidic, basic or amphoteric polysaccharide. According to some embodiments, a crosslinked structure and a tissue adhesive material comprising the crosslinked structure are provided, in which the crosslinked structure comprises (a) a polysaccharide derivative having such a structure that a group represented by formula (A) is introduced into an acidic, basic or amphoteric polysaccharide and (b) at least one of an amino-group-containing polymer and an amino-group-containing low-molecular-weight compound each containing at least two primary amino groups, hydrazide groups or aminooxy groups and a group represented by formula (x1), and the crosslinking is achieved by the covalent bonding between a primary amino group, a hydrazide group or an aminooxy group contained in the amino-group-containing polymer and the amino-group-containing low-molecular-weight compound and the group represented by formula (A) contained in the polysaccharide derivative through a Schiff base. According to some embodiments, a tissue adhesive material having a gel-like form is provided, which comprises a polysaccharide derivative having such a structure that a group represented by formula (A-2) is introduced into a polysaccharide containing an amino group, in which the group represented by formula (A-2) is introduced into the polysaccharide by substituting for a hydrogen atom in the amino group in the polysaccharide to form an amide bond.

公开(公告)号：EP4459623A1

公开(公告)日：2024-11-06

申请号：EP23740304.3

申请日：2023-01-12

Applicant: The University of Tokyo

Inventor： YOKOYAMA Kazuaki

IPC: G16B30/00 ,  G16B20/20 ,  G16H50/20

Abstract: The purpose of the present invention is to improve the efficiency and convenience of analyzing the degree of likelihood that a mutation is one that affects the development or progression of a disease. A common filter unit 53 of an analysis device 1 for selecting a cancer driver mutation in a subject classifies, on the basis of a first classification criteria, each of a plurality of sequence mutations identified by sequencing nucleic acids included in the subject into a rank from among rank MYC1 for which the likelihood of being selected as a target sequence mutation is the highest and ranks MYC2 to MYC4 for which the above likelihood is lower than that for MYC1. A parameter-setting reception unit 542 sets, as a second classification criteria, a classification criteria of having been registered in a database or a list, the second classification criteria being different from the first classification criteria for carrying out classification into rank MYC1. A seed gene filter 541 reclassifies, into rank MYC1, a sequence mutation that satisfies the second classification criteria from among the sequence mutations classified into ranks MYC2 to MYC4. The problem is thereby solved.

公开(公告)号：EP4455190A1

公开(公告)日：2024-10-30

申请号：EP22910903.8

申请日：2022-12-07

Applicant: Shiseido Company, Ltd. ,  The University of Tokyo

Inventor： MATSUO, Ayano ,  GILLET, Renaud ,  SOGABE, Atsushi ,  HONDA, Satoshi ,  OKA, Minami

IPC: C08G77/52

Abstract: A polymer compound in which coumarin or a derivative thereof is bonded to at least one terminal of a skeletal polymer. A flow property of the polymer compound is reversibly changeable from a first state to a second state by irradiation with light at a first wavelength and from the second state to the first state by irradiation with light at a second wavelength different from the first wavelength.

公开(公告)号：EP4442714A1

公开(公告)日：2024-10-09

申请号：EP22901126.7

申请日：2022-11-18

Applicant: The University of Tokyo ,  Resonac Corporation ,  Japan Polyethylene Corporation

Inventor： NOZAKI, Kyoko ,  SEIDEL, Falk William ,  AKITA, Shumpei ,  KIMURA, Kento ,  KURODA, Junichi ,  UEMATSU, Masahiro ,  SAKURAGI, Tsutomu

IPC: C08F4/80 ,  C08F10/02

CPC classification number: C08F4/80 ,  C08F10/02

Abstract: Provided are a catalyst and a method that enable the production of an olefin-based polymer, which has a polar group and is usable for various applications, at high catalytic activity. A metal complex shown in general formula (C1) (in the formula, M represents a palladium atom or a nickel atom, X represents a phosphorus atom (P), R5-R9 are as set forth in the claims, L represents an electron donating ligand, and q is 0, 1/2, 1, or 2) is used as a catalyst for polymerization of an olefin having a polar group.

公开(公告)号：EP4442555A1

公开(公告)日：2024-10-09

申请号：EP22901274.5

申请日：2022-11-29

Applicant: Nippon Telegraph And Telephone Corporation ,  The University of Tokyo

Inventor： HANZAWA, Nobutomo ,  NAKAJIMA, Kazuhide ,  MATSUI, Takashi ,  MURAYAMA, Hideaki ,  WADA, Ryota

IPC: B63B35/00 ,  B63B35/03 ,  B63B35/04 ,  G01B11/16 ,  G01B11/24

CPC classification number: B63B35/03 ,  G01B11/24 ,  B63B35/04 ,  B63B35/00 ,  G01B11/16

Abstract: An object of the present disclosure is to enable collection of information indicating a state of an underwater structure, and thereby improve the efficiency and reliability of an above-water system including above-water and underwater structures connected to each other.
The present disclosure is a control system configured to: collect a strain distribution of an underwater structure connected to an above-water structure; and control at least one of the underwater structure and the above-water structure in accordance with the strain distribution.

公开(公告)号：EP4416282A1

公开(公告)日：2024-08-21

申请号：EP22879697.5

申请日：2022-10-14

Applicant: The University of Queensland ,  The University of Tokyo

Inventor： CRAIK, David James ,  DE VEER, Simon John ,  HUANG, Yen-Hua ,  SWEDBERG, Joakim Erik ,  SUGA, Hiroaki ,  LIU, Wenyu ,  PASSIOURA, Toby

IPC: C12N15/10 ,  G01N33/68 ,  A61K38/00 ,  A61P29/00 ,  A61P7/02 ,  C07K14/415 ,  C40B30/04

CPC classification number: A61P7/02 ,  A61P29/00 ,  C07K14/415 ,  C40B30/04 ,  C12N15/1062 ,  A61K38/56

公开(公告)号：EP4410959A1

公开(公告)日：2024-08-07

申请号：EP22872587.5

申请日：2022-08-10

Applicant: The University of Tokyo ,  NISSIN FOODS HOLDINGS CO., LTD.

Inventor： TAKEUCHI, Shoji ,  MORIMOTO, Yuya ,  FURUHASHI, Mai

IPC: C12N5/071 ,  A23L13/00 ,  C12N5/077

CPC classification number: C12N5/00 ,  A23L13/00 ,  C12N5/06

Abstract: The present invention addresses the problem of providing, as a scaffold material, a cell culture gel that utilizes plasma from adult bovine blood, rather than using extracellular matrix. The present invention further addresses the problem of producing cells using, as the scaffold material for cell culture, a cell culture gel that utilizes plasma from adult bovine blood. The cell culture gel according to the present invention contains: plasma derived from adult bovine blood, and a coagulant.

公开(公告)号：EP4382346A1

公开(公告)日：2024-06-12

申请号：EP22852984.8

申请日：2022-08-01

Applicant: Mitsubishi Jidosha Kogyo Kabushiki Kaisha ,  The University of Tokyo

Inventor： TAKAHASHI, Ryota ,  FUJIMOTO, Hiroshi ,  FUSE, Hiroyuki ,  TAKAHASHI, Naoki ,  MATSUO, Shunsuke ,  OKAMURA, Yutaro ,  KOGA, Ryosuke

IPC: B60L15/20 ,  B60W10/04 ,  B60W30/02

CPC classification number: Y02T10/72 ,  B60W10/04 ,  B60L15/20 ,  B60W30/02

Abstract: The vehicle control device (10) includes: an arithmetic unit (11) that calculates a target slip ratio (y) serving as a target value of a slip ratio (λ) of the wheel (5); a limiting unit (12) that sets an upper limit value (ymax) of the target slip ratio (y), the upper limit value (ymax) being based on at least a vehicle velocity (V) of the vehicle (1), and limits the target slip ratio (y) calculated by the arithmetic unit (11) to a value equal to or less than the upper limit value (ymax); and a controlling unit (13) that controls driving torque of the vehicle (1) such that a wheel velocity that achieves the target slip ratio (y) limited by the limiting unit (12) is obtained.

公开(公告)号：EP4382345A1

公开(公告)日：2024-06-12

申请号：EP22852983.0

申请日：2022-08-01

Applicant: Mitsubishi Jidosha Kogyo Kabushiki Kaisha ,  The University of Tokyo

Inventor： TAKAHASHI, Naoki ,  FUJIMOTO, Hiroshi ,  FUSE, Hiroyuki ,  TAKAHASHI, Ryota ,  OKAMURA, Yutaro ,  KOGA, Ryosuke ,  FURUICHI, Tetsuya ,  MARUYAMA, Akira

IPC: B60L15/20 ,  F16H48/06 ,  B60K17/12

CPC classification number: F16H48/06 ,  B60K17/12 ,  B60L15/20

Abstract: A control system for a vehicle (1) provided with a differential mechanism (3) that applies a torque difference to left and right wheels (5) and two electric motors (2) coupled to the differential mechanism (3), the control system including: two control units (11, 12) being connected to each other via high-speed communication means and each controlling one of the two electric motors (2); a first rotation speed sensor (26R) that detects a first rotation speed of a first electric motor (2R) of the two electric motors (2) and outputs the first rotation speed to the two control units (11, 12); a second rotation speed sensor (26L) that detects a second rotation speed of a second electric motor (2L) of the two electric motors (2) and outputs the second rotation speed to the two control units (11, 12); and a superordinate control unit (10) that calculates demanded torques of the two electric motors (2) based on vehicle information of the vehicle (1). At least a first control unit of the two control unites (11, 12) calculates two assigned torques to achieve the demanded torques calculated in the superordinate control unit (10) based on detection signals of the two rotation speed sensors (26R, 26L).

公开(公告)号：EP4375661A1

公开(公告)日：2024-05-29

申请号：EP22845900.4

申请日：2022-07-19

Applicant: Shimadzu Corporation ,  The University of Tokyo

Inventor： KANEKO, Naoki ,  TOMITA, Taisuke ,  MATSUZAKI, Masaya ,  YOKOYAMA, Miyabishara

IPC: G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  A01K67/027 ,  C07K14/705

CPC classification number: C07K14/705 ,  G01N33/50 ,  G01N33/53 ,  A01K67/027 ,  G01N33/15

Abstract: A level of mouse Aβ1-40 and a level of mouse APP669-711 in a biological sample derived from an AD model mouse are measured by detection of markers including mouse Aβ1-40 and mouse APP669-711; an APP669-711/Aβ1-40 ratio which is a ratio of the level of mouse APP669-711 to the level of mouse Aβ1-40 is calculated; and when the ratio in the AD model mouse is higher than the same ratio in a reference mouse in which cerebral Aβ deposition is absent, it is judged that an amount of cerebral Aβ deposition in the AD model mouse is higher than an amount of cerebral Aβ deposition in the reference mouse.