发明公开
EP2402367A1 Library from toxin mutants, and methods of using same
审中-公开
Bibliothek aus Toxinmutanten und Verwendungsverfahrendafür
- 专利标题： Library from toxin mutants, and methods of using same
- 专利标题（中）： Bibliothek aus Toxinmutanten und Verwendungsverfahrendafür
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申请号： EP11168475.9申请日： 2006-09-26
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公开(公告)号： EP2402367A1公开(公告)日： 2012-01-04
- 发明人: Gariepy, Jean , Revers, Leigh
- 申请人： Molecular Templates, Inc.
- 申请人地址： 111 W. Cooperative Way, Suite 201 Georgetown, TX 78626 US
- 专利权人： Molecular Templates, Inc.
- 当前专利权人： Molecular Templates, Inc.
- 当前专利权人地址： 111 W. Cooperative Way, Suite 201 Georgetown, TX 78626 US
- 代理机构： Modiano, Micaela Nadia
- 优先权： US720924P 20050926
- 主分类号： C07K14/245
- IPC分类号： C07K14/245 ; C12Q1/18 ; C40B30/04 ; C40B40/10 ; G01N33/566 ; G01N33/58
摘要：
This application relates to libraries of ABx toxin mutants, in which a peptide insert is introduced into the protease- sensitive loop of the A-chain sequence to alter the type of cells to which toxic species are delivered. Said libraries are used in the development of therapeutics targeted against specific cell types.
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