公开(公告)号：EP4431519A1

公开(公告)日：2024-09-18

申请号：EP22883600.3

申请日：2022-10-19

Applicant: The University of Tokyo

Inventor： SUGA, Hiroaki ,  GOTO, Yuki ,  ZHANG Yuchen ,  OKADA, Masahiro

IPC: C07K1/113 ,  C40B40/08 ,  C40B40/10 ,  C12N15/11 ,  C12P21/02 ,  C12N9/10

CPC classification number: C07K1/113 ,  C12N9/10 ,  C12N15/11 ,  C12P21/02 ,  C40B40/08 ,  C40B40/10

Abstract: The present invention relates to a method for producing compounds that have at least one of the structures represented by the following formula (I) or (II), the method comprising a step of contacting a compound having at least one structure represented by the following formula (III) or (IV) with a prenyltransferase to introduce a prenyl group into the structure, wherein the prenyltransferase is LimF or an enzyme homologous thereto.

公开(公告)号：EP4361267A1

公开(公告)日：2024-05-01

申请号：EP22828547.4

申请日：2022-06-24

Applicant: Repertoire Genesis Incorporation

Inventor： SUZUKI, Ryuji ,  SHIN-I, Tadasu ,  NAKAMURA, Yukio ,  SASAMURA, Takeshi

IPC: C12N15/11 ,  C07K14/705 ,  C07K14/725 ,  C12Q1/68 ,  C40B40/10 ,  G01N33/53

CPC classification number: C07K14/705 ,  C12Q1/68 ,  C12N15/11 ,  C40B40/10 ,  G01N33/53

Abstract: According to the present disclosure, there is provided a method for identifying an epitope sequence.
The present disclosure provides a method for identifying an epitope sequence associated with a specific physiological state of a test subject, the method including the steps of: A) obtaining BCR and/or TCR repertoire data associated with the specific physiological state of the test subject; B) specifying a TREM sequence (repertoire specific TREM sequence) from the BCR and/or TCR repertoire data; C) obtaining a reference TREM sequence associated with the test subject; D) specifying a repertoire-reference common specific TREM sequence from the reference TREM sequence and the repertoire specific TREM sequence; and E) determining, based on the repertoire-reference common specific TREM sequence, whether a peptide sequence including the repertoire-reference common specific TREM sequence is an epitope sequence associated with the specific physiological state of the test subject.

公开(公告)号：EP4341298A1

公开(公告)日：2024-03-27

申请号：EP22829199.3

申请日：2022-06-22

Applicant: University of Virginia Patent Foundation

Inventor： BARKER, Thomas, H. ,  SHETTY, Jagathpala

IPC: C07K16/28 ,  C40B40/10 ,  C40B20/04 ,  G01N33/564

公开(公告)号：EP4281557A1

公开(公告)日：2023-11-29

申请号：EP22743405.7

申请日：2022-01-18

Applicant: Hope Patents, LLC

Inventor： KAUFFMAN, Stuart ,  HUANG, Sui

IPC: C12N15/10 ,  C12N15/85 ,  C40B30/06 ,  C40B40/02 ,  C40B40/08 ,  C40B40/10 ,  G01N33/50

公开(公告)号：EP3580561B1

公开(公告)日：2023-11-01

申请号：EP18707815.9

申请日：2018-02-12

Inventor： ABELIN, Jennifer, Grace ,  OSLUND, Rob, Carl ,  HACOHEN, Nir ,  BARTHELME, Dominik ,  ROONEY, Michael

IPC: G01N33/50 ,  C40B30/04 ,  A61K39/00 ,  C40B40/02 ,  G01N33/574 ,  G01N33/68 ,  C12Q1/6886 ,  A61K39/39 ,  C40B40/10 ,  G16B35/20

公开(公告)号：EP4220162A2

公开(公告)日：2023-08-02

申请号：EP22208330.5

申请日：2022-11-18

Applicant: Leica Microsystems CMS GmbH

Inventor： Alsheimer, Soeren

IPC: G01N33/532 ,  G01N33/58 ,  C12Q1/6876 ,  C40B40/06 ,  C40B40/10 ,  G01N33/533

Abstract: A connector (802) for analysing biological sample is provided comprising: a nucleic acid backbone (804); at least one linker oligonucleotide (806) comprising a first affinity interactor (808), the linker oligonucleotide (806) at least partially hybridised to a complementary part of the nucleic acid backbone (804). The first affinity interactor (808) is configured to specifically bind to a label (810) comprising a second affinity interactor (820). In further aspects, a connector-label conjugate (1000), a marker (800, 1002) and method and device to generate those are provided.

公开(公告)号：EP4166675A1

公开(公告)日：2023-04-19

申请号：EP21828111.1

申请日：2021-06-25

Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA

Inventor： NISHIMURA, Kaori ,  TANIGUCHI, Takaaki ,  SHINOHARA, Shojiro ,  KAGOTANI, Mana ,  MISAIZU, Miki

IPC: C12P21/02 ,  C12N15/09 ,  C40B30/04 ,  C40B40/10

Abstract: The present inventors used aminoacylated tRNAs prepared by ligating a pCpA-amino acid to a tRNA lacking the 3'-terminal CA sequence using a ligase, and thereby succeeded in discrimination between the NNA and NNG codons in specific codon boxes, which had been difficult to achieve due to the presence of wobble base pairing. Furthermore, the inventors assigned another amino acid to the NNU or NNC codon in the same codon box, and performed translation of a sequence containing the NNU, NNA, and NNG codons, or the NNC, NNA, and NNG codons to evaluate the codon discrimination ability. As a result, the codons of interest were specifically translated into only the corresponding amino acids, achieving accurate discrimination successfully. Furthermore, the inventors confirmed that similar effects can also be obtained even when the nucleotide sequence of the tRNA body is altered.

公开(公告)号：EP4139473A1

公开(公告)日：2023-03-01

申请号：EP20743471.3

申请日：2020-06-29

Applicant: Google LLC

Inventor： WASSIE, Asmamaw ,  PAWLOSKY, Annalisa Marie ,  CHAVARHA, Mariya ,  JESS, Phillip ,  BERNDL, Marc

IPC: C12Q1/68 ,  G01N33/543 ,  C40B40/10 ,  C12N15/10

公开(公告)号：EP4126928A1

公开(公告)日：2023-02-08

申请号：EP21774044.8

申请日：2021-03-22

Applicant: CDI Laboratories Inc.

Inventor： HULETT, Tyler

IPC: C07K16/00 ,  C40B40/10

公开(公告)号：EP4074829A1

公开(公告)日：2022-10-19

申请号：EP20899836.9

申请日：2020-12-11

Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA

Inventor： YOSHII, Sakiko ,  SHIMOMURA, Koichiro ,  ISHINO, Sou

IPC: C12N15/31 ,  C07K7/04 ,  C07K7/64 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/11 ,  C12N15/63 ,  C12P21/02 ,  C40B30/04 ,  C40B40/10 ,  G01N33/15 ,  G01N33/50

Abstract: The present invention revealed that translating an mRNA that encodes a peptide containing an unnatural amino acid in a translation system that contains a ribosome containing an engineered L31 protein can increase the amount of the translated peptide. Furthermore, the invention revealed that by using this ribosome, the relative amount of by-products can also be reduced. An engineered L31 protein of the present invention has an amino acid sequence with deletion of 6 or more amino acid residues from the C terminus in the amino acid sequence of the wild-type Escherichia coli L31 protein.