发明公开
- 专利标题： PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
- 专利标题（中）： 嘧啶衍生物作为抑制剂MTOR
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申请号： EP10707924.6申请日： 2010-03-12
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公开(公告)号： EP2406258A1公开(公告)日： 2012-01-18
- 发明人: LYNCH, Rosemary , CANSFIELD, Andrew , NIBLOCK, Helen Sarah , HARDY, Daniel , SCANLON, Jane Elizabeth , ADREGO, Rita , RAMSDEN, Nigel
- 申请人： Cellzome Limited
- 申请人地址： Chesterford Research Park Little Chesterford Cambridgeshire CB10 1XL GB
- 专利权人： Cellzome Limited
- 当前专利权人： Cellzome Limited
- 当前专利权人地址： Chesterford Research Park Little Chesterford Cambridgeshire CB10 1XL GB
- 代理机构： Büchel, Edwin
- 优先权： EP09155143 20090313; US303252P 20100210
- 国际公布： WO2010103094 20100916
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D487/04 ; A61K31/519 ; A61P37/00
摘要：
The invention relates to compounds of Formula (I) wherein X, R
1 , R
2 , T, m, n, o have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
1 , R
2 , T, m, n, o have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
公开/授权文献
- EP2406258B1 PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS 公开/授权日：2014-12-03
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