公开(公告)号：EP2057158B1

公开(公告)日：2015-08-12

申请号：EP07803060.8

申请日：2007-08-30

申请人： Cellzome Limited

发明人： WILSON, Francis ,  RAMSDEN, Nigel ,  BELL, Kathryn ,  CANSFIELD, Andrew ,  BURCKHARDT, Svenja ,  TAYLOR, Jess ,  SUNOSE, Mihiro ,  MIDDLEMISS, David

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P29/00 ,  A61P37/00 ,  A61P35/00

CPC分类号： C07D471/04

公开(公告)号：EP2855451A1

公开(公告)日：2015-04-08

申请号：EP13724816.7

申请日：2013-05-23

申请人： Cellzome Limited

发明人： HARRISON, Richard John ,  RAMSDEN, Nigel ,  MAJOR, Jeremy ,  MOREL, Adeline ,  CONVERY, Laura ,  SUNOSE, Mihiro ,  LYNCH, Rosemary ,  ADREGO, Rita ,  JONES, Alison

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/14 ,  A61K31/505 ,  A61P37/00

CPC分类号： A61K31/506 ,  A61K31/505 ,  A61K31/5377 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D487/10 ,  C07D491/048 ,  C07D491/107

摘要： The present invention relates to compounds of formula (I), wherein R, R
1 , X
1 to X
5 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments.

摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 1，X 1至X 5具有在说明书和权利要求书中引用的含义。 所述化合物可用作治疗或预防免疫学，炎性，自身免疫性，过敏性疾病和免疫介导的疾病的TYK2抑制剂。 本发明还涉及包含所述化合物的药物组合物以及它们作为药物的用途。

公开(公告)号：EP2760863A1

公开(公告)日：2014-08-06

申请号：EP12762577.0

申请日：2012-09-20

申请人： Cellzome Limited

发明人： RAMSDEN, Nigel ,  DAGOSTIN, Claudio

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/519 ,  A61P37/06

CPC分类号： A61K31/519 ,  A61K31/437 ,  C07D471/04 ,  C07D487/04

摘要： The present invention relates to compounds of formula (I) wherein X
1 to X
5 , Y, Z
A , Z
B , R and A have the meaning as cited in the description and the claims. Said compounds are useful as kinase inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically- mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as the use as medicaments.

公开(公告)号：EP2758379A1

公开(公告)日：2014-07-30

申请号：EP12761738.9

申请日：2012-09-21

申请人： Cellzome Limited

发明人： LYNCH, Rosemary ,  CANSFIELD, Andrew David ,  HARDY, Daniel Paul ,  SUNOSE, Mihiro ,  MOREL, Adeline ,  CONVERY, Laura ,  ADREGO, Rita

IPC分类号： C07D251/22 ,  C07D401/12 ,  C07D407/12 ,  C07D413/04 ,  A61K31/53 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  A61P37/08 ,  A61P35/00

CPC分类号： C07D498/08 ,  C07D251/22 ,  C07D401/12 ,  C07D407/12 ,  C07D413/04 ,  C07D413/14

摘要： The invention relates to compounds of formula (I), wherein m, n, R
1 , T
0 and T
1 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds as well as the use as medicaments.

公开(公告)号：EP2379552B1

公开(公告)日：2014-02-26

申请号：EP09797025.5

申请日：2009-12-16

申请人： Janssen Pharmaceuticals, Inc. ,  Cellzome Limited

发明人： GIJSEN, Henricus, Jacobus, Maria ,  MACDONALD, Gregor, James ,  BISCHOFF, François, Paul ,  TRESADERN, Gary, John ,  TRABANCO-SUÁREZ, Andrés, Avelino ,  VAN BRANDT, Sven, Franciscus, Anna ,  BERTHELOT, Didier, Jean-Claude

IPC分类号： C07D471/04 ,  A61K31/4188 ,  A61P25/28

CPC分类号： C07D471/04

公开(公告)号：EP2638018A1

公开(公告)日：2013-09-18

申请号：EP11781515.9

申请日：2011-11-07

申请人： Cellzome Limited

发明人： ELLARD, Katie ,  MAJOR, Jeremy ,  JONES, Alison ,  LYNCH, Rosemary ,  RAMSDEN, Nigel

IPC分类号： C07D239/42 ,  C07D403/12 ,  A61K31/505 ,  A61K31/506 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D239/42 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to compounds of formula (I), wherein R
1 to R
3 , X
1 , X
2 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments.

公开(公告)号：EP2588105A1

公开(公告)日：2013-05-08

申请号：EP11727491.0

申请日：2011-06-28

申请人： Cellzome Limited

发明人： ELLARD, Katie ,  RAMSDEN, Nigel

IPC分类号： A61K31/4196 ,  C07D249/20 ,  A61P37/02 ,  A61P37/08 ,  A61P37/06 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/4196 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to compounds of Formula (I), wherein R
1 to R
6 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immuno logically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments.

公开(公告)号：EP2215043B1

公开(公告)日：2013-03-06

申请号：EP08839085.1

申请日：2008-10-17

申请人： Janssen Pharmaceutica, N.V. ,  Cellzome Limited

发明人： HO, Chih Yung ,  ZHANG, Yan ,  BURCKHARDT, Svenja ,  JONES, Alison

IPC分类号： C07C57/42 ,  C07C57/58 ,  C07C57/60 ,  C07C59/56 ,  C07C59/88 ,  C07C255/57 ,  C07D213/61 ,  A61K31/192 ,  A61P25/28

CPC分类号： C07C59/88 ,  C07C57/42 ,  C07C57/58 ,  C07C57/60 ,  C07C59/56 ,  C07C255/57 ,  C07D213/61

公开(公告)号：EP2542536A1

公开(公告)日：2013-01-09

申请号：EP11706815.5

申请日：2011-03-04

申请人： Cellzome Limited

发明人： LYNCH, Rosemary ,  CANSFIELD, Andrew, David ,  NIBLOCK, Helen, Sarah ,  HARDY, Daniel, Paul ,  TAYLOR, Jessica

IPC分类号： C07D239/42 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  A61K31/5377 ,  A61P37/00 ,  C07D498/08

CPC分类号： C07D413/14 ,  A61K31/5377 ,  C07D239/42 ,  C07D401/04 ,  C07D413/04 ,  C07D498/08

摘要： The invention relates to compounds of formula (I) wherein X
1 , X
2 , R
1 to R
4 , m, n have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

公开(公告)号：EP2475648A1

公开(公告)日：2012-07-18

申请号：EP10771368.7

申请日：2010-09-07

申请人： Cellzome Limited

发明人： HARRISON, Richard, John ,  HOBSON, Andrew ,  RAMSDEN, Nigel

IPC分类号： C07D239/48 ,  C07D403/12 ,  A61K31/505 ,  A61K31/506 ,  A61P37/00 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D239/48

摘要： The present invention relates to compounds of formula (I), wherein X
1 to X
3 , R, R
2 to R
7 and AA have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

摘要翻译： 本发明涉及式（I）的化合物，其中X 1至X 3，R，R 2至R 7和AA具有在说明书和权利要求书中引用的含义。 所述化合物可用作JAK抑制剂，用于治疗或预防免疫，炎症，自身免疫，过敏性疾病和免疫介导的疾病。 本发明还涉及包含所述化合物的药物组合物，所述化合物的制备以及作为药物的用途。