发明公开
EP2407545A4 AUXOTROPHIC, RECOMBINANT BCG STRAIN PASTEUR AND USE THEREOF FOR COMBATING HUMAN INFECTIONS CAUSED BY PARASITES
有权
营养缺陷型重组BCG巴斯德菌株及其用于防治在人体寄生虫相关性感染
- 专利标题： AUXOTROPHIC, RECOMBINANT BCG STRAIN PASTEUR AND USE THEREOF FOR COMBATING HUMAN INFECTIONS CAUSED BY PARASITES
- 专利标题（中）： 营养缺陷型重组BCG巴斯德菌株及其用于防治在人体寄生虫相关性感染
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申请号： EP10750256申请日： 2010-03-10
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公开(公告)号： EP2407545A4公开(公告)日： 2013-06-19
- 发明人: TENDLER MIRIAM , VILAR MONICA MAGNO , ARMOA GERALDO RODRIGUES GARCIA , MCINTOSH DOUGLAS , SIMPSON ANDREW J G
- 申请人： FUNDACAO OSWALDO CRUZ
- 专利权人： FUNDACAO OSWALDO CRUZ
- 当前专利权人： FUNDACAO OSWALDO CRUZ
- 优先权： BRPI0900896 2009-03-11
- 主分类号： C12N15/76
- IPC分类号： C12N15/76 ; A61P31/06 ; A61P33/10 ; A61P35/00
摘要：
The present invention relates to a vaccinal strain of recombinant BCG Mycobacterium bovis expressing the Schistossoma mansoni Sm14 protein (BCG Pasteur ”leuD/p”K410-hsp60*-Sm14). The vaccinal strain of the present invention is employed in the control of infections caused by parasites, specially the Schistossoma mansoni. The vaccinal strain is a an auxotrophic strain to leucine amino acid derived from the BCG Pasteur sub-strain complemented to leucine after genetic transformation with the construct p”K410-hsp60*-Sm14. The efficacy of the BCG Pasteur ”leuD/p”K410-hsp60*-Sm14 strain in the control of the Schistossoma mansoni infection based on the recombinant Sm14 antigen in vivo is showed in the present invention.
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