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    SOLID PHARMACEUTICAL COMPOSITION OF DED ANOSINE
    3.
    发明公开
    SOLID PHARMACEUTICAL COMPOSITION OF DED ANOSINE 审中-公开
    FESTE PHARMAZEUTISCHE ZUSAMMENSETZUNG VON DIDANOSIN

    公开(公告)号：EP2221049A2

    公开(公告)日：2010-08-25

    申请号：EP08849054.5

    申请日：2008-11-13

    申请人： Blanver Farmoquimica, LTDA ,  Fundacao Oswaldo Cruz (Fiocruz)-Instituto de Tecnoligia em Farmacos (FARMANGUINHOS)

    发明人： TICÓ GRAU, José, Ramon ,  SUÑÉ NEGRE, José, Maria

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K31/505

    CPC分类号： A61K31/505 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/5026 ,  A61K9/5047

    摘要： The present invention relates to a new solid pharmaceutical composition of didanosine comprising didanosine crystals with an average particle size comprised between 50 and 500 microns, coated by a layer of an enteric coating. The pharmaceutical composition of the invention can be prepared by means of a simple process, which comprises coating the didanosine crystals with an enteric layer. Said composition has a good stability of the active ingredient, as well as a suitable release in the conditions present in the upper part of the gastrointestinal tract. It also relates to the use of said composition for preparing solid dosage forms of didanosine for their oral administration. The invention also relates to tablets and to hard gelatin capsules containing said composition.

    摘要翻译： 本发明涉及一种包含平均粒度为50-500微米的去羟肌苷结晶的去羟肌苷的新的固体药物组合物，由一层肠溶衣包被。 本发明的药物组合物可以通过简单的方法制备，其包括用去霉素层包被去羟肌苷晶体。 所述组合物具有良好的活性成分的稳定性，以及在胃肠道上部存在的条件下的合适的释放。 它还涉及所述组合物用于制备用于口服给药的去羟肌苷的固体剂型的用途。 本发明还涉及含有所述组合物的片剂和硬明胶胶囊。

    METHOD FOR THE PRODUCTION OF RECOMBINANT VIRUS, DNA CONSTRUCTS, RECOMBINANT VIRUS AND VACCINE COMPOSITIONS
    6.
    发明公开
    METHOD FOR THE PRODUCTION OF RECOMBINANT VIRUS, DNA CONSTRUCTS, RECOMBINANT VIRUS AND VACCINE COMPOSITIONS 有权
    一种用于生产重组黄病毒，DNA构建体，重组黄病毒和疫苗组合物的过程中

    公开(公告)号：EP1989316A2

    公开(公告)日：2008-11-12

    申请号：EP06804595.4

    申请日：2006-10-31

    申请人： Fundacao Oswaldo Cruz - Fiocruz

    发明人： BONALDO, Myrna Cristina ,  GALLER, Ricardo

    IPC分类号： C12N15/86 ,  C12N15/63 ,  A61K35/76 ,  A61K48/00

    CPC分类号： A61K39/12 ,  A61K2039/525 ,  A61K2039/5256 ,  A61K2039/575 ,  C07K14/005 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/40 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24143 ,  C12N2770/24171 ,  Y02A50/386 ,  Y02A50/388

    摘要： The purpose of the present invention is the production of recombinant virus through the cloning and expression of sequences of coding nucleotides of the whole or part of heterolog proteins, through the following method: (a) modification of the heterolog nucleotides sequences in such way they when cloned and expressed in the vector virus, they present in the 5′ region, nucleotides present in the 5′ edge of the gene NS1 of this vector virus or of other virus or equivalent functional sequences, and in its 3′ region, the correspondent genome region in the whole or part of the spheres of the steam and anchor of the protein E of this vector virus or equivalent functional sequences, and not compromising the structure and the replication of the mention vector virus; (b) insertion of the modified heterolog sequences in (a) in the intergene region at the structural protein E level and of on structural NS1 vector virus; (c) obtention of the non pathogenic recombinant virus and owner of the immunologic properties, having the heterolog sequences integrated in the viral genome according to the insertion described in (b) and, like that, expressing the heterolog antigene in such way that it can induce an appropriate immune response. The present invention is also addressed to vaccine compositions to immune against the Flavivirus and/or other pathogens.

    TRYPANOSOMA CRUZI RECOMBINANT ANTIGENS AND SYNTHETIC PEPTIDES FOR UTILIZATION INTHE IMMUNOLOGICAL DIAGNOSIS OF CHAGAS DISEASE
    9.
    发明公开
    TRYPANOSOMA CRUZI RECOMBINANT ANTIGENS AND SYNTHETIC PEPTIDES FOR UTILIZATION INTHE IMMUNOLOGICAL DIAGNOSIS OF CHAGAS DISEASE 失效
    克氏锥虫的重组抗原和免疫学诊断南美锥虫病合成肽。

    公开(公告)号：EP0486627A1

    公开(公告)日：1992-05-27

    申请号：EP91906678.0

    申请日：1991-04-01

    申请人： FUNDACAO OSWALDO CRUZ (FIOCRUZ)

    发明人： GOLDENBERG, Samuel ,  KRIEGER, Marco Aurelio, Rua Desembargador Antonio ,  CERQUEIRA DE ALMEIDA, Elza Carmen

    IPC分类号： C07K14 ,  C12N15 ,  A61K38

    CPC分类号： C07K14/44 ,  A61K38/00 ,  Y02A50/414

    摘要： This patent deals with the use of Trypanosoma cruzi antigens obtained using recombinant DNA techniques, or synthetic peptides derived from these antigens, and their use in the immunological diagnosis of Chagas Disease using either ELISA, or western blot, or dot-blot, or hemagglutination, or agglutination, or monoclonal antibodies, or radioimmunoassay. The antigens or synthetic peptides are characterized by displaying the following aminoacid sequences: Ag1: valine (or alanine), alanine, glutamic acid, alanine (orthreonine), glutamic acid, lysine, glutamine, lysine (or arginine), alanine, alanine, glutamic acid, alanine (or serine), threonine (or methionine or alanine) and lysine. Ag2: methionine, glutamic acid, glutamine, glutamic acid arginine, arginine, glutamine, leucine, leucine, glutamic acid, lysine, aspartic acid, proline, arginine, arginine, asparagine, alanine, lysine, glutamic acid, isoleucine alanine, alanine, leucine, glutamic acid, glutamic acid, serine, methionine, asparagine, alanine, arginine, alanine, glutamine, glutamic acid, leucine, alanine, arginine, glutamic acid, lysine, lysine, leucine, arginine, aspartic acid, arginine, alanine, phenylalanine, leucine, aspartic acid, glutamine, lysine, proline, glutamic acid, arginine, valine, proline, leucine, alanine, aspartic acid, valine, proline, leucine, aspartic acid, aspartic acid, aspartic acid, serine, aspartic acid, phenylalanine, valine and alanine.