发明公开
EP2408804A1 VACCINE COMPOSITIONS AND METHODS FOR TREATMENT OF MUCORMYCOSIS AND OTHER FUNGAL DISEASES
审中-公开
疫苗组合物和用于治疗粘液瘤和其他真菌疾病的方法
- 专利标题： VACCINE COMPOSITIONS AND METHODS FOR TREATMENT OF MUCORMYCOSIS AND OTHER FUNGAL DISEASES
- 专利标题（中）： 疫苗组合物和用于治疗粘液瘤和其他真菌疾病的方法
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申请号： EP10753820.9申请日： 2010-03-19
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公开(公告)号： EP2408804A1公开(公告)日： 2012-01-25
- 发明人: IBRAHIM, Ashraf, S. , SPELLBERG, Brad, J. , FU, Yue , EDWARDS, John, E.
- 申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- 申请人地址： 1124 West Carson Street Torrance, CA 90502 US
- 专利权人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- 当前专利权人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- 当前专利权人地址： 1124 West Carson Street Torrance, CA 90502 US
- 代理机构： Jones Day
- 优先权： US161614P 20090319
- 国际公布： WO2010107500 20100923
- 主分类号： C07K14/00
- IPC分类号： C07K14/00 ; C07K16/00
摘要：
The present invention provides therapeutic compositions and methods for treating and preventing fungal disease or conditions including mucormycosis. The therapeutic methods and compositions of the invention include vaccine compositions having an FTR polypeptide or an antigenic fragment of the polypeptide; a vector including a nucleotide sequence that is substantially complimentary to at least 18 contiguous nucleotides of FTR sequence; an antisense; a small interfering RNA or an antibody inhibitor of FTR. The vaccine compositions of the invention can further include an adjuvant.
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