公开(公告)号：EP2755681B1

公开(公告)日：2018-06-27

申请号：EP12831998.5

申请日：2012-09-14

申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

发明人： IBRAHIM, Ashraf, S. ,  LIU, Mingfu ,  GHEBREMARIAM, Teklegiorgis ,  FU, Yue ,  EDWARDS, John, E. ,  FILLER, Scott

IPC分类号： A61K39/00 ,  A61K48/00 ,  C07K14/37 ,  C07K16/14 ,  G01N33/569

CPC分类号： C07K16/14 ,  A61K2039/505 ,  C07K14/37 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/56961 ,  G01N2333/37 ,  G01N2469/10

摘要： The invention provided Mucorales CotH polypeptides and encoding nucleic acid molecules. The Mucorales CotH polypeptides and encoding nucleic acids can be advantageously used to diagnose, treat or prevent fungal conditions, in particular mucormycosis.

公开(公告)号：EP2968497B1

公开(公告)日：2020-08-12

申请号：EP14764623.6

申请日：2014-03-14

申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center ,  Novadigm Therapeutics, Inc.

发明人： IBRAHIM, Ashraf, S. ,  YEAMAN, Michael, R. ,  FILLER, Scott, G. ,  EDWARDS, John, E., Jr. ,  HENNESSEY, John, P., Jr.

IPC分类号： A61K39/00 ,  A61K39/38

公开(公告)号：EP2408804A1

公开(公告)日：2012-01-25

申请号：EP10753820.9

申请日：2010-03-19

申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

发明人： IBRAHIM, Ashraf, S. ,  SPELLBERG, Brad, J. ,  FU, Yue ,  EDWARDS, John, E.

IPC分类号： C07K14/00 ,  C07K16/00

CPC分类号： C07K16/14 ,  A61K2039/505 ,  C12N9/00 ,  C12N15/1138 ,  C12N2310/14

摘要： The present invention provides therapeutic compositions and methods for treating and preventing fungal disease or conditions including mucormycosis. The therapeutic methods and compositions of the invention include vaccine compositions having an FTR polypeptide or an antigenic fragment of the polypeptide; a vector including a nucleotide sequence that is substantially complimentary to at least 18 contiguous nucleotides of FTR sequence; an antisense; a small interfering RNA or an antibody inhibitor of FTR. The vaccine compositions of the invention can further include an adjuvant.

摘要翻译： 本发明提供治疗和预防包括毛霉菌病在内的真菌疾病或病症的治疗组合物和方法。 本发明的治疗方法和组合物包括具有FTR多肽或多肽的抗原性片段的疫苗组合物; 包含与FTR序列的至少18个连续核苷酸基本互补的核苷酸序列的载体; 反义词; 小干扰RNA或FTR的抗体抑制剂。 本发明的疫苗组合物可以进一步包含佐剂。

公开(公告)号：EP2968497A2

公开(公告)日：2016-01-20

申请号：EP14764623.6

申请日：2014-03-14

申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center ,  Novadigm Therapeutics, Inc.

发明人： IBRAHIM, Ashraf, S. ,  YEAMAN, Michael, R. ,  FILLER, Scott, G. ,  EDWARDS, John, E., Jr. ,  HENNESSEY, John, P., Jr.

IPC分类号： A61K39/00 ,  A61K39/38

摘要： The invention features fragments of the Candida cell surface proteins Als3 and Hyr1 and combinations thereof useful in immunizing a subject against fungal or bacterial infections or both.

摘要翻译： 本发明提供了念珠菌细胞表面蛋白Als3和Hyr1的片段以及它们的组合，可用于免疫受试者抵抗真菌或细菌感染或两者。

公开(公告)号：EP2707023A2

公开(公告)日：2014-03-19

申请号：EP12785706.8

申请日：2012-05-11

申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

发明人： SPELLBERG, Brad, J. ,  LIN, Lin ,  IBRAHIM, Ashraf, S. ,  LUO, Guanpingsheng

IPC分类号： A61K39/02 ,  C07K14/21 ,  C07K7/08 ,  C07K7/06 ,  C07K5/08 ,  C12N15/31 ,  C12N15/63 ,  C07K16/12 ,  A61K39/395 ,  A61P31/04 ,  A61P37/04

CPC分类号： C07K14/22 ,  A61K39/02 ,  A61K39/104 ,  A61K2039/55505 ,  C07K14/212 ,  C07K16/1203 ,  C07K16/1217 ,  C07K2317/34

摘要： The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization against A.
baumannii infection. The invention also provides antibodies and antigen-binding parts thereof that specifically bind to OmpA, and related methods of passive immunization against A.
baumannii infection. The compositions and methods of the invention are useful for preventing or treating A.
baumannii infections, including those caused by strains resistant to carbapenems and all other antibiotics except colistin or tigecycline, also referred to as extreme drug resistant (XDR) A.
baumannii infections, and those resistant to every FDA approved antibiotic, also referred to as pan-drug resistant (PDR) A.
baumannii infections.

公开(公告)号：EP2043636A2

公开(公告)日：2009-04-08

申请号：EP07796874.1

申请日：2007-07-13

申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

发明人： IBRAHIM, Ashraf, S. ,  SPELLBERG, Brad, J. ,  EDWARDS, John, E.

IPC分类号： A61K31/4196 ,  A61K31/4412 ,  A61K31/7048 ,  A61P31/10

CPC分类号： A61K31/4196 ,  A61K31/4412 ,  A61K31/7048 ,  A61K45/06 ,  Y02A50/492 ,  A61K2300/00

摘要： The invention provides a composition including at least one iron chelating compound for use in a method of treating or preventing a fungal condition. The composition can include the iron chelating compounds deferiprone or deferasirox. An antifungal agent included in the composition can include a polyene antifungal agent, an azole antifungal agent or an echinocandin antifungal agent. The method includes administering to an individual having, or susceptible to having, a fungal condition a therapeutically effective amount of at least one iron chelating compound for a sufficient time to reduce the severity of a fungal condition, wherein the iron chelating compound comprises a non-siderophore or non-xenosiderophore relative to the fungal condition. Provided further by the invention is the prophylactic administration of the at least one iron chelating compound or at least one iron chelating compound prior to onset of the fungal condition.

公开(公告)号：EP2755681A2

公开(公告)日：2014-07-23

申请号：EP12831998.5

申请日：2012-09-14

申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

发明人： IBRAHIM, Ashraf, S. ,  LIU, Mingfu ,  GHEBREMARIAM, Teklegiorgis ,  FU, Yue ,  EDWARDS, John, E. ,  FILLER, Scott

IPC分类号： A61K39/00 ,  C12N15/74 ,  A61K48/00

CPC分类号： C07K16/14 ,  A61K2039/505 ,  C07K14/37 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/56961 ,  G01N2333/37 ,  G01N2469/10

摘要： The invention provided Mucorales CotH polypeptides and encoding nucleic acid molecules. The Mucorales CotH polypeptides and encoding nucleic acids can be advantageously used to diagnose, treat or prevent fungal conditions, in particular mucormycosis.

公开(公告)号：EP2755668A2

公开(公告)日：2014-07-23

申请号：EP12832321.9

申请日：2012-09-14

申请人： Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

发明人： IBRAHIM, Ashraf, S. ,  YEAMAN, Michael, R. ,  EDWARDS, John, E., Jr. ,  LUO, Guanpingsheng ,  FU, Yue

IPC分类号： A61K36/06 ,  C07K14/00 ,  A61K38/00 ,  C12Q1/68

CPC分类号： C07K14/40 ,  A61K39/00 ,  A61K39/0002 ,  A61K47/646 ,  A61K2039/6081 ,  C07K16/14

摘要： The invention features isolated polypeptides of Hyrl. The invention further features vaccines and antibodies useful in treating or preventing candidiasis or Acinetobacter infections or both.