发明公开
EP2411365A1 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS
有权
2,3-二芳基或杂芳基取代的1,1,1-三氟-2-羟基丙基化合物
- 专利标题： 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS
- 专利标题（中）： 2,3-二芳基或杂芳基取代的1,1,1-三氟-2-羟基丙基化合物
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申请号： EP10709740.4申请日： 2010-03-23
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公开(公告)号： EP2411365A1公开(公告)日： 2012-02-01
- 发明人: HUNZIKER, Daniel , LERNER, Christian , MUELLER, Werner , OBST SANDER, Ulrike , PFLIEGER, Philippe , WALDMEIER, Pius
- 申请人： F.Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.Hoffmann-La Roche AG
- 当前专利权人： F.Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Sauer, Frank
- 优先权： EP09156267 20090326
- 国际公布： WO2010108903 20100930
- 主分类号： C07D213/63
- IPC分类号： C07D213/63 ; C07D235/26 ; C07D263/58 ; C07D265/36 ; C07D285/14 ; C07D317/46 ; C07D317/54 ; C07D401/12 ; C07D413/12 ; C07D455/02 ; C07D498/04 ; A61K31/536 ; A61K31/5415 ; C07C255/53 ; A61P3/10
摘要：
The present invention relates to compounds of formula (I), wherein R
1a to R
1e , R
2 , R
3 and R
5 are as defined in the description and claims and R
4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically 5 acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
1a to R
1e , R
2 , R
3 and R
5 are as defined in the description and claims and R
4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically 5 acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
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