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公开(公告)号：EP4397309A3
公开(公告)日：2024-09-04
申请号：EP24152498.2
申请日：2018-07-12
发明人： PATEL, Snahel , HAMILTON, Gregory , ZHAO, Guiling , CHEN, Huifen , DANIELS, Blake , STIVALA, Craig
IPC分类号： C07D487/04 , C07D498/04 , A61P25/16 , A61P25/28 , A61K31/41 , A61K31/437 , A61K31/5365
CPC分类号： C07D487/04 , A61P25/16 , A61P25/28 , C07D498/04 , A61P17/06 , A61P21/00 , A61P19/02 , A61P1/00 , C07D235/12 , C07D471/04
摘要： The invention provides novel compounds having the general formula I:
wherein R', the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.-
公开(公告)号：EP4412995A1
公开(公告)日：2024-08-14
申请号：EP22800510.4
申请日：2022-10-04
申请人： Genentech, Inc.
发明人： GRANDNER, Jessica Marie , JOHNSON, Kevin M. , MAGNUSON, Steven , MURRAY, Jeremy Mark , PARR, Brendan T. , VERMA, Vishal A. , WANG, Yong , ZENG, Mingshuo , ASHLEY, Melissa A.
IPC分类号： C07D401/12 , C07D403/12 , A61P35/00
CPC分类号： C07D403/12 , C07D401/12 , A61P35/00
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公开(公告)号：EP4313986A1
公开(公告)日：2024-02-07
申请号：EP22718464.5
申请日：2022-04-01
发明人： HONG, Allen Y. , WONG, Nicholas , KELLY, Sean M. , SIROIS, Lauren Elizabeth , SCHWEGLER, Sara , LINGHU, Xin , GOSSELIN, Francis , PIECHOWICZ, Katarzyna Aleksandra , MOLINARO, Carmela , WETZL, Dennis
IPC分类号： C07D487/04 , C07D207/273 , C12P7/62
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公开(公告)号：EP3953356B1
公开(公告)日：2023-07-26
申请号：EP20717841.9
申请日：2020-04-07
发明人： ZHU, Wei , ZHANG, Zhiwei , ZHANG, Zhisen , SHEN, Hong , LIU, Yongfu , LIU, Yafei , LIU, Haixia , KOU, Buyu , DEY, Fabian , DAI, Lue , ZHU, Linuo
IPC分类号： C07D487/04 , C07D519/00 , A61P37/00 , A61K31/4985
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公开(公告)号：EP4165026A1
公开(公告)日：2023-04-19
申请号：EP21732050.6
申请日：2021-06-14
发明人： KALDRE, Dainis , SEDELMEIER, Joerg
IPC分类号： C07D239/70
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公开(公告)号：EP4093509A1
公开(公告)日：2022-11-30
申请号：EP21709504.1
申请日：2021-01-20
发明人： GIBBONS, Paul , LAI, Kwong Wah , NILEWSKI, Christian , PASTOR, Richard M. , STABEN, Steven Thomas , STIVALA, Craig , ZHU, Bing-Yan , CHEN, Huifen
IPC分类号： A61P29/00 , A61P35/00 , C07D498/04 , C07D498/10 , A61K31/424 , A61K31/4439 , A61K31/506 , A61K31/5365
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公开(公告)号：EP4049660A1
公开(公告)日：2022-08-31
申请号：EP21217196.1
申请日：2017-02-27
发明人： MAO, Chen , KOU, Dawen , CHIANG, Po-Chang
摘要： The invention relates generally to pharmaceutical tablet compositions comprising fumaric acid and the compound (S)-2-(3'-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro- [3,4'-bipyridin]-2'-yl)-7,7-dimethyl-2,3,4,6,7,8-hexahydro-1H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one free base that is an inhibitor of Bruton's tyrosine kinase. The invention further relates to amorphous solid dispersions comprising at least one polymer and the Bruton's kinase inhibitor free base compound. The invention further relates to crystalline mesylate salts, crystalline chloride salts and crystalline sulfate salts of the Bruton's kinase inhibitor free base compound. In some aspects, the crystalline salts are single polymorphs.
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公开(公告)号：EP3914250A1
公开(公告)日：2021-12-01
申请号：EP20708271.0
申请日：2020-01-21
IPC分类号： A61K31/496 , A61K31/573 , A61K31/519 , A61K45/06 , A61P19/02 , A61P37/06 , A61K9/00 , G01N33/50
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公开(公告)号：EP3521288B1
公开(公告)日：2021-09-08
申请号：EP19152979.1
申请日：2012-11-02
IPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D495/04 , C07D519/00 , A61K31/4985 , C07D487/14 , A61K31/381 , A61K31/4353 , A61P35/00 , A61P37/00
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10.发明公开
公开(公告)号：EP3865482A1
公开(公告)日：2021-08-18
申请号：EP20207475.3
申请日：2017-08-28
发明人： GAO, Lu , LIANG, Chungen , YUN, Hongying , ZHENG, Xiufang , WANG, Jianping , MIAO, Kun , ZHANG, Bo
IPC分类号： C07D473/24 , A61K31/522 , A61P31/00
摘要： The present invention relates to compounds of formula (I),
wherein R 1 , R 2 and R 3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
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