发明公开
EP2424533A1 SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS -SECRETASE INHIBITORS
审中-公开
取代的异喹啉衍生物，药物组合物，井井有条用作β-分泌酶抑制剂
- 专利标题： SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS -SECRETASE INHIBITORS
- 专利标题（中）： 取代的异喹啉衍生物，药物组合物，井井有条用作β-分泌酶抑制剂
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申请号： EP10770133.6申请日： 2010-04-20
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公开(公告)号： EP2424533A1公开(公告)日： 2012-03-07
- 发明人: MJALLI, Adnan M. M. , GADDAM, Bapu , GOHIMUKKULA, Devi Reddy , POLISETTI, Dharma Rao , EL ABDELLAOUI, Hassan , RAO, Mohan , WANG, Pingzhen , ANDREWS, Robert Carl , XIE, Rongyuan , REN, Tan
- 申请人： High Point Pharmaceuticals, LLC
- 申请人地址： 4170 Mendenhall Oaks Parkway High Point, NC 27265 US
- 专利权人： High Point Pharmaceuticals, LLC
- 当前专利权人： High Point Pharmaceuticals, LLC
- 当前专利权人地址： 4170 Mendenhall Oaks Parkway High Point, NC 27265 US
- 代理机构： Cooke, Richard Spencer
- 优先权： US173176P 20090427
- 国际公布： WO2010126743 20101104
- 主分类号： A61K31/47
- IPC分类号： A61K31/47
摘要：
The present invention is directed to substituted isoquinoline derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.
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