专利检索 ap:("High Point Pharmaceuticals, LLC") AND inv:"WANG, Pingzhen" 第 1 页

1.

发明公开
SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS -SECRETASE INHIBITORS 审中-公开
标题翻译：取代的异喹啉衍生物，药物组合物，井井有条用作β-分泌酶抑制剂

公开(公告)号：EP2424533A1

公开(公告)日：2012-03-07

申请号：EP10770133.6

申请日：2010-04-20

申请人： High Point Pharmaceuticals, LLC

发明人： MJALLI, Adnan M. M. , GADDAM, Bapu , GOHIMUKKULA, Devi Reddy , POLISETTI, Dharma Rao , EL ABDELLAOUI, Hassan , RAO, Mohan , WANG, Pingzhen , ANDREWS, Robert Carl , XIE, Rongyuan , REN, Tan

IPC分类号： A61K31/47

CPC分类号： C07D401/12 , C07D401/14

摘要： The present invention is directed to substituted isoquinoline derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.