发明公开
EP2438050A1 NOVEL DERIVATIVES OF ARYL-{4-HALOGENO-4-[AMINOMETHYL]-PIPERIDIN-1-YL}-METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS
有权
NEW芳{4-卤代-4- [氨基甲基] - 哌啶-1-基} -METHANONDERIVATE，它们的制备方法及其作为MEDICAL DEVICES
- 专利标题： NOVEL DERIVATIVES OF ARYL-{4-HALOGENO-4-[AMINOMETHYL]-PIPERIDIN-1-YL}-METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS
- 专利标题（中）： NEW芳{4-卤代-4- [氨基甲基] - 哌啶-1-基} -METHANONDERIVATE，它们的制备方法及其作为MEDICAL DEVICES
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申请号： EP10724750.4申请日： 2010-06-03
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公开(公告)号： EP2438050A1公开(公告)日： 2012-04-11
- 发明人: VACHER, Bernard , COLPAERT, Francis , MAUREL, Jean-Louis
- 申请人： Pierre Fabre Medicament
- 申请人地址： 45, Place Abel Gance 92100 Boulogne-Billancourt FR
- 专利权人： Pierre Fabre Medicament
- 当前专利权人： Pierre Fabre Medicament
- 当前专利权人地址： 45, Place Abel Gance 92100 Boulogne-Billancourt FR
- 代理机构： Ahner, Francis
- 优先权： FR0953725 20090605
- 国际公布： WO2010139758 20101209
- 主分类号： C07D265/36
- IPC分类号： C07D265/36 ; C07D413/12 ; A61K31/538 ; A61P25/24 ; A61P25/00
摘要：
The present invention concerns compounds of general formula (1) (I) wherein R1 is: - a hydrogen atom, or a halogen, - a straight or branched C
1 -C
6 alkyl group or a C
1 -C
3 fluoroalkyl group, - a straight or branched C
1 -C
6 alcoxy group, a carbamyl group, N-substituted or not by one or two, straight or branched C
1 -C
3 alkyl groups, or - a cyano group (CN) R2 is: - a hydrogen atom or a straight or branched C
1 -C
6 alkyl group, HaI
1 , Hal
2 and Hal
3 are: - a halogen their addition salts and the hydrates of addition salts with pharmaceutically acceptable mineral acids or organic acids, and their enantiomer forms.
1 -C
6 alkyl group or a C
1 -C
3 fluoroalkyl group, - a straight or branched C
1 -C
6 alcoxy group, a carbamyl group, N-substituted or not by one or two, straight or branched C
1 -C
3 alkyl groups, or - a cyano group (CN) R2 is: - a hydrogen atom or a straight or branched C
1 -C
6 alkyl group, HaI
1 , Hal
2 and Hal
3 are: - a halogen their addition salts and the hydrates of addition salts with pharmaceutically acceptable mineral acids or organic acids, and their enantiomer forms.
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