利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

31 条记录 (耗时 0.018 秒)

    PROCEDE DE SYNTHESE ET INTERMEDIAIRES DE BENZOXATHIEPINES
    2.
    发明公开
    PROCEDE DE SYNTHESE ET INTERMEDIAIRES DE BENZOXATHIEPINES 有权
    合成方法和BENZOXATHIEPINZWISCHENPRODUKTE

    公开(公告)号：EP1735297A1

    公开(公告)日：2006-12-27

    申请号：EP05753693.0

    申请日：2005-04-08

    申请人： PIERRE FABRE MEDICAMENT

    发明人： VACHER, Bernard ,  BRUNEL, Yves ,  CASTAN-CUISIAT, Florence

    IPC分类号： C07D327/02 ,  C07C323/22

    CPC分类号： C07D327/02 ,  C07C323/52

    摘要： The invention relates to preparing derivatives of formula (1), wherein, in particular R1 and R2, identical or different, represent a hydrogen, fluorine or chlorine atom, a hydroxy group, an alkyl radical and an alkoxy radical, R3 is an alkyl radical, a hydroxy group or a methoxy radical, R4 is a hydrogen atom or a methyl radical and R5 and R6, identical or different, represent a hydrogen atom, an alkyl radical, an alkoxy radical, an alkylthio radical and an alkylamino radical. The inventive method consists in reducing an amid of formula (9).

    NOUVEAUX DERIVES D'ARYL-4-HALOGENO-4- HETEROARYLMETHYLAMINO)-METHYL]-PIPERIDIN-1-YL-METHANONE,LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENTS
    3.
    发明公开
    NOUVEAUX DERIVES D'ARYL-4-HALOGENO-4- HETEROARYLMETHYLAMINO)-METHYL]-PIPERIDIN-1-YL-METHANONE,LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENTS 有权
    NOUVEAUX衍生物D'ARYL-4-卤代戊酸4-杂芳基甲基氨基） - 甲基] - 哌啶-1-基 - 甲酮，LEUR方法和制备方法以及使用的药物

    公开(公告)号：EP1539738A1

    公开(公告)日：2005-06-15

    申请号：EP03760060.8

    申请日：2003-06-18

    申请人： PIERRE FABRE MEDICAMENT

    发明人： VACHER, Bernard ,  BONNAUD, Bernard ,  MAUREL, Jean-Louis ,  COLPAERT, Francis

    IPC分类号： C07D401/12 ,  A61K31/506 ,  A61P25/00

    CPC分类号： C07D401/12

    摘要： The invention relates to compounds of general formula (1) in which X and Y = a carbon with a bonded hydrogen atom (CH) or a nitrogen atom, A = a methyl, fluoromethyl, cyano, hydroxyl, methoxy group, or a chlorine or fluorine atom on condition that when A = methyl (CH3) and X and Y both = a carbon bonded to a hydrogen atom, then B = a chlorine atom, B = a chlorine or a fluorine atom, D = a hydrogen, chlorine, fluorine atom, or a cyano or trifluoromethyl group and E = a hydrogen, fluorine or chlorine atom.

    摘要翻译： 本发明涉及通式（1）的化合物，其中X和Y =具有键合的氢原子（CH）或氮原子的碳，A =甲基，氟甲基，氰基，羟基，甲氧基或氯或 当A =甲基（CH3）且X和Y均为=与氢原子键合的碳时，则B =氯原子，B =氯或氟原子，D =氢，氯，氟 原子或氰基或三氟甲基，E =氢，氟或氯原子。

    DERIVES BENZOAXATHIEPINES ET LEUR UTILISATION COMME MEDICAMENTS
    4.
    发明授权
    DERIVES BENZOAXATHIEPINES ET LEUR UTILISATION COMME MEDICAMENTS 有权
    BENZOAXATHIEPIN衍生物及其医药用途

    公开(公告)号：EP1370547B1

    公开(公告)日：2004-09-15

    申请号：EP02759802.8

    申请日：2002-03-20

    申请人： PIERRE FABRE MEDICAMENT

    发明人： VACHER, Bernard ,  CASTANT-CUISIAT, Florence ,  JOHN, Gareth ,  LEGRAND, Bruno

    IPC分类号： C07D327/02 ,  C07C323/22 ,  A61K31/39 ,  A61P9/10

    CPC分类号： C07C323/22 ,  C07D327/02

    摘要： The invention concerns 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiepin derivatives of general formula (I), wherein: R1 and R2, identical or different, represent a hydrogen atom, a fluorine atom or a chlorine atom, a hydroxy group, an alkyl, cyclopropyl, alkoxy, cyclopropoxy radical or when they occupy adjacent positions, form with the carbon atoms bearing them a carbon-containing cycle or an oxygen-containing heterocycle with five non-aromatic rings; R3 represents an alkyl radical, a hydroxy group or a methoxy radical; R4 represents a hydrogen atom or a methyl radical; and R5 and R6, identical or different represent a hydrogen atom, an alkyl, alkoxy, alkylthio, alkylamino radical, or the groups OR4 and R5 form with the carbons which bear them a non-aromatic heterocycle with five or six rings containing at least an oxygen atom; and their pharmaceutically acceptable additions salts.

    DERIVES BENZOAXATHIEPINES ET LEUR UTILISATION COMME MEDICAMENTS
    8.
    发明公开
    DERIVES BENZOAXATHIEPINES ET LEUR UTILISATION COMME MEDICAMENTS 有权
    BENZOAXATHIEPIN衍生物及其医药用途

    公开(公告)号：EP1370547A1

    公开(公告)日：2003-12-17

    申请号：EP02759802.8

    申请日：2002-03-20

    申请人： PIERRE FABRE MEDICAMENT

    发明人： VACHER, Bernard ,  CASTANT-CUISIAT, Florence ,  JOHN, Gareth ,  LEGRAND, Bruno

    IPC分类号： C07D327/02 ,  C07C323/22 ,  A61K31/39 ,  A61P9/10

    CPC分类号： C07C323/22 ,  C07D327/02

    摘要： The invention concerns 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiepin derivatives of general formula (I), wherein: R1 and R2, identical or different, represent a hydrogen atom, a fluorine atom or a chlorine atom, a hydroxy group, an alkyl, cyclopropyl, alkoxy, cyclopropoxy radical or when they occupy adjacent positions, form with the carbon atoms bearing them a carbon-containing cycle or an oxygen-containing heterocycle with five non-aromatic rings; R3 represents an alkyl radical, a hydroxy group or a methoxy radical; R4 represents a hydrogen atom or a methyl radical; and R5 and R6, identical or different represent a hydrogen atom, an alkyl, alkoxy, alkylthio, alkylamino radical, or the groups OR4 and R5 form with the carbons which bear them a non-aromatic heterocycle with five or six rings containing at least an oxygen atom; and their pharmaceutically acceptable additions salts.