发明公开
- 专利标题： NOVEL CYCLOPENTANE DERIVATIVES
- 专利标题（中）： 消除周期性
-
申请号： EP10724803.1申请日： 2010-06-08
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公开(公告)号： EP2440521A1公开(公告)日： 2012-04-18
- 发明人: BANNER, David , CECCARELLI, Simona M. , GRETHER, Uwe , HAAP, Wolfgang , HILPERT, Hans , KUEHNE, Holger , MAUSER, Harald , PLANCHER, Jean-Marc , SANCHEZ, Rubén Alvarez
- 申请人： F.Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.Hoffmann-La Roche AG
- 当前专利权人： F.Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Pomeranc, Didier
- 优先权： EP09162510 20090611
- 国际公布： WO2010142650 20101216
- 主分类号： C07C317/44
- IPC分类号： C07C317/44 ; C07D205/04 ; C07D207/02 ; C07D211/36 ; C07D213/60 ; C07D231/12 ; C07D233/18 ; C07D249/04 ; C07D261/08 ; C07D265/30 ; C07D295/185 ; C07D309/12 ; C07D335/02 ; A61K31/277 ; A61P3/10
摘要：
The invention relates to compounds of formula (I) wherein A
1 , R
1 , R
2 , R
3 , R
4 and R
5 are defined in the description and in the claims, which are preferential inhibitors of the cysteine protease cathepsin, in particular of the cysteine protease cathepsin S or L, making them useful as medicaments, particularly in the treatment of diabetes, atherosclerosis, abdominal aortic aneurysm, peripheral arterial disease or diabetic nephropathy.
1 , R
1 , R
2 , R
3 , R
4 and R
5 are defined in the description and in the claims, which are preferential inhibitors of the cysteine protease cathepsin, in particular of the cysteine protease cathepsin S or L, making them useful as medicaments, particularly in the treatment of diabetes, atherosclerosis, abdominal aortic aneurysm, peripheral arterial disease or diabetic nephropathy.
公开/授权文献
- EP2440521B1 NOVEL CYCLOPENTANE DERIVATIVES 公开/授权日：2014-04-30
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