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公开(公告)号：EP2888244A1
公开(公告)日：2015-07-01
申请号：EP13750339.7
申请日：2013-08-19
发明人： ANSELM, Lilli , BANNER, David , HAAP, Wolfgang , KUHN, Bernd , LUEBBERS, Thomas , PETERS, Jens-Uwe , SPINNLER, Beat
IPC分类号： C07D401/14 , A61K31/4439 , A61K31/444
CPC分类号： C07D401/08 , A61K9/2054 , A61K9/4858 , C07D401/14
摘要： The invention relates to a compound of formula (I) wherein A
1 , A
2 and R
1 to R
6 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.-
公开(公告)号：EP2421826B1
公开(公告)日：2013-10-23
申请号：EP10713457.9
申请日：2010-04-13
发明人： ALVAREZ SANCHEZ, Ruben , BANNER, David , CECCARELLI, Simona M. , GRETHER, Uwe , HAAP, Wolfgang , HARTMAN, Peter , HARTMANN, Guido , HILPERT, Hans , KUEHNE, Holger , MAUSER, Harald , PLANCHER, Jean-Marc
IPC分类号： C07D207/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12
CPC分类号： C07D207/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/04
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公开(公告)号：EP1846381A2
公开(公告)日：2007-10-24
申请号：EP05817940.9
申请日：2005-12-14
发明人： BOEHRINGER, Markus , GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , HILPERT, Hans , PANDAY, Narendra , RICKLIN, Fabienne
IPC分类号： C07D277/46 , C07D401/10 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/10 , C07D417/14
CPC分类号： C07D401/10 , C07D277/46 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/10 , C07D417/14
摘要： The invention is concerned with novel heteroarylacetamides of formula (I) Rd-C(O)-N(Re)-Rc-CH2-C(O)-N(Ra)(Rb), wherein Ra to Re are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
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公开(公告)号：EP2032548A1
公开(公告)日：2009-03-11
申请号：EP07729351.2
申请日：2007-05-22
发明人： GUBLER, Marcel , HAAP, Wolfgang , HEBEISEN, Paul , KITAS, Eric A. , KUHN, Bernd , MINDER, Rudolf E. , SCHOTT, Brigitte , WESSEL, Hans P.
IPC分类号： C07D277/38 , C07D277/58 , C07D277/82 , C07D417/04 , C07D417/12 , C07D417/14
CPC分类号： C07D277/48 , C07D277/54 , C07D277/56 , C07D277/58 , C07D277/82 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 have the significance given in claim 1 and which can be used in the form of pharmaceutical compositions.
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5.发明公开
公开(公告)号：EP1928864A1
公开(公告)日：2008-06-11
申请号：EP06778383.7
申请日：2006-08-28
发明人： GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , HILPERT, Hans , PANDAY, Narendra , RICKLIN, Fabienne
IPC分类号： C07D409/12 , C07D413/12 , A61K31/4427 , A61K31/5377 , A61P7/02
CPC分类号： C07D413/12 , C07D409/12
摘要： The invention is concerned with novel cycloalkane carboxamides of Formula (I) wherein X, X1, Y, Y1’, R1’’, R1, R2, R3, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
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公开(公告)号：EP3083644A1
公开(公告)日：2016-10-26
申请号：EP14821587.4
申请日：2014-12-17
发明人： GUBA, Wolfgang , HAAP, Wolfgang , KUGLSTATTER, Andreas , PETERS, Jens-Uwe , OBST SANDER, Ulrike , SCHNIDER, Christian , WERMUTH, Roger , WOLTERING, Thomas
IPC分类号： C07D513/04 , A61K31/549 , A61K31/554 , A61P25/28
CPC分类号： C07D513/04
摘要： The present invention provides a compound of formula I' having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：EP2814822B1
公开(公告)日：2016-04-20
申请号：EP13703826.1
申请日：2013-02-14
IPC分类号： C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D417/08 , C07D417/14 , A61K31/401 , A61P3/00
CPC分类号： C07D417/14 , C07D207/10 , C07D401/14 , C07D403/06 , C07D403/08 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/08
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公开(公告)号：EP2782903B1
公开(公告)日：2016-04-06
申请号：EP12788530.9
申请日：2012-11-20
发明人： BANNER, David , HAAP, Wolfgang , KUHN, Bernd , LUEBBERS, Thomas , PETERS, Jens-Uwe , SCHULZ-GASCH, Tanja
IPC分类号： C07D207/16 , C07D401/08 , C07D403/04 , C07D405/12 , C07D413/12 , A61K31/4155 , A61K31/401 , A61K31/423 , A61K31/4439 , A61K31/4025 , A61K31/5377 , A61P3/10 , A61P9/00 , A61P35/00 , A61P27/00
CPC分类号： C07D413/12 , C07D207/16 , C07D401/06 , C07D401/08 , C07D403/04 , C07D405/12
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公开(公告)号：EP2814822A1
公开(公告)日：2014-12-24
申请号：EP13703826.1
申请日：2013-02-14
IPC分类号： C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D417/08 , C07D417/14 , A61K31/401 , A61P3/00
CPC分类号： C07D417/14 , C07D207/10 , C07D401/14 , C07D403/06 , C07D403/08 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/08
摘要： The invention relates to a compound of formula (I) wherein A
1 to A
3 and R
1 to R
3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.-
公开(公告)号：EP2440521B1
公开(公告)日：2014-04-30
申请号：EP10724803.1
申请日：2010-06-08
发明人： BANNER, David , CECCARELLI, Simona M. , GRETHER, Uwe , HAAP, Wolfgang , HILPERT, Hans , KUEHNE, Holger , MAUSER, Harald , PLANCHER, Jean-Marc , SANCHEZ, Rubén Alvarez
IPC分类号： C07C317/44 , C07D205/04 , C07D207/02 , C07D211/36 , C07D213/60 , C07D231/12 , C07D233/18 , C07D249/04 , C07D261/08 , C07D265/30 , C07D295/185 , C07D309/12 , C07D335/02 , A61K31/277 , A61P3/10
CPC分类号： C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D205/04 , C07D207/06 , C07D207/10 , C07D207/16 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/66 , C07D213/34 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D231/12 , C07D237/08 , C07D237/14 , C07D237/16 , C07D239/26 , C07D249/06 , C07D261/08 , C07D277/26 , C07D279/12 , C07D295/096 , C07D295/185 , C07D309/12 , C07D333/18 , C07D335/02 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/12 , C07D491/08 , C07D491/107
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