发明授权
- 专利标题： APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS
- 专利标题（中）： 凋亡信号调节激酶抑制剂
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申请号： EP10733116.7申请日： 2010-07-12
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公开(公告)号： EP2454250B1公开(公告)日： 2015-01-14
- 发明人: CORKEY, Britton , GRAUPE, Michael , KOCH, Keith , MELVIN, Lawrence S. , NOTTE, Gregory
- 申请人： Gilead Sciences, Inc.
- 申请人地址： 333 Lakeside Drive Foster City, CA 94404 US
- 专利权人： Gilead Sciences, Inc.
- 当前专利权人： Gilead Sciences, Inc.
- 当前专利权人地址： 333 Lakeside Drive Foster City, CA 94404 US
- 代理机构： Wallace, Sheila Jane
- 优先权： US289263P 20091222; US225076P 20090713; US225079P 20090713
- 国际公布： WO2011008709 20110120
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; C07D407/14 ; C07D413/14 ; C07D471/04 ; C07D491/048 ; A61K31/437 ; A61K31/4439 ; A61K31/444 ; A61K31/497 ; A61K31/506 ; A61P9/00 ; A61P25/28 ; A61P29/00 ; A61P37/00
摘要：
The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
公开/授权文献
- EP2454250A1 APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS 公开/授权日：2012-05-23
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