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公开(公告)号：EP2933252A1
公开(公告)日：2015-10-21
申请号：EP15151030.2
申请日：2010-07-12
IPC分类号： C07D401/12 , C07D401/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D491/048 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61P9/00 , A61P25/28 , A61P29/00 , A61P37/00
CPC分类号： A61K31/444 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/585 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048
摘要： The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
摘要翻译： 本发明涉及式（I）化合物：其中X1，X2，X3，X4，X5，X6，X7，X8，R1，R2，R3如上定义。 该化合物具有凋亡信号调节激酶（“ASK1”）抑制活性，因此可用于治疗ASK1介导的病症，包括自身免疫性疾病，炎性疾病，心血管疾病和神经变性疾病。 本发明还涉及包含一种或多种式（I）化合物的药物组合物和制备式（I）化合物的方法。
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公开(公告)号：EP2454250B1
公开(公告)日：2015-01-14
申请号：EP10733116.7
申请日：2010-07-12
IPC分类号： C07D401/12 , C07D401/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D491/048 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61P9/00 , A61P25/28 , A61P29/00 , A61P37/00
CPC分类号： A61K31/444 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/585 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048
摘要： The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
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公开(公告)号：EP3363797B1
公开(公告)日：2020-12-02
申请号：EP17208659.7
申请日：2010-07-12
发明人： CORKEY, Britton , GRAUPE, Michael , KOCH, Keith
IPC分类号： C07D401/12 , C07D401/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D491/048 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61P9/00 , A61P25/28 , A61P29/00 , A61P37/00 , A61K31/585 , A61K31/5377 , A61K31/496 , A61K31/4709 , A61K45/06
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公开(公告)号：EP2454250A1
公开(公告)日：2012-05-23
申请号：EP10733116.7
申请日：2010-07-12
IPC分类号： C07D401/12 , C07D401/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D491/048 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61P9/00 , A61P25/28 , A61P29/00 , A61P37/00
CPC分类号： A61K31/444 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/585 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048
摘要： The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
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公开(公告)号：EP3363797A8
公开(公告)日：2021-04-28
申请号：EP17208659.7
申请日：2010-07-12
IPC分类号： C07D401/12 , C07D401/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D491/048 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61P9/00 , A61P25/28 , A61P29/00 , A61P37/00 , A61K31/585 , A61K31/5377 , A61K31/496 , A61K31/4709 , A61K45/06
摘要： The present invention relates to compounds of Formula (I): wherein X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , X 8 , R 1 , R 2 , R 3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
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公开(公告)号：EP2464645B1
公开(公告)日：2017-07-05
申请号：EP10737724.4
申请日：2010-07-26
发明人： CORKEY, Britton , ELZEIN, Elfatih , JIANG, Robert , KALLA, Rao , KOBAYASHI, Tetsuya , KOLTUN, Dmitry , LI, Xiaofen , NOTTE, Gregory , PARKHILL, Eric , PERRY, Thao , ZABLOCKI, Jeff
IPC分类号： C07D471/04 , A61K31/437 , A61K31/519 , A61K31/4985 , A61K31/5025 , A61P9/00
CPC分类号： C07D487/04 , C07D471/04
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公开(公告)号：EP2588475A1
公开(公告)日：2013-05-08
申请号：EP11734220.4
申请日：2011-06-30
发明人： CORKEY, Britton , NOTTE, Gregory , ZABLOCKI, Jeff
IPC分类号： C07D409/14 , C07D417/14 , A61K31/4196 , A61K31/427 , A61K31/4427 , A61P9/00 , A61P29/00 , A61P37/00
CPC分类号： C07D409/14
摘要： The present invention relates to compounds of Formula (I): wherein X1, X2, X3, X4, X5, R, R1, R2 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
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公开(公告)号：EP3858824A1
公开(公告)日：2021-08-04
申请号：EP20210819.7
申请日：2010-07-12
IPC分类号： C07D401/12 , C07D401/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D491/048 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61P9/00 , A61P25/28 , A61P29/00 , A61P37/00 , A61K31/4196
摘要： The present invention relates to compounds of Formula (I): wherein X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , X 8 , R 1 , R 2 , R 3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
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公开(公告)号：EP3363797A1
公开(公告)日：2018-08-22
申请号：EP17208659.7
申请日：2010-07-12
发明人： CORKEY, Britton , GRAUPE, Michael , KOCH, Keith
IPC分类号： C07D401/12 , C07D401/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D491/048 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61P9/00 , A61P25/28 , A61P29/00 , A61P37/00 , A61K31/585 , A61K31/5377
CPC分类号： A61K31/444 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/585 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048
摘要： The present invention relates to compounds of Formula (I): wherein X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , X 8 , R 1 , R 2 , R 3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
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公开(公告)号：EP2933252B1
公开(公告)日：2018-01-03
申请号：EP15151030.2
申请日：2010-07-12
IPC分类号： C07D401/12 , C07D401/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D491/048 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61P9/00 , A61P25/28 , A61P29/00 , A61P37/00
CPC分类号： A61K31/444 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/585 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/048
摘要： The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase ("ASK1") inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
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